InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ptprq

Summary

InnateDB Protein

IDBP-189189.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptprq

Protein Name

protein tyrosine phosphatase, receptor type, Q

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000058572

InnateDB Gene

IDBG-189187 (Ptprq)

Protein Structure

UniProt Annotation

Function

Phosphatidylinositol phosphatase required for auditory function. May act by regulating the level of phosphatidylinositol 4,5-bisphosphate (PIP2) level in the basal region of hair bundles. Can dephosphorylate a broad range of phosphatidylinositol phosphates, including phosphatidylinositol 3,4,5-trisphosphate and most phosphatidylinositol monophosphates and diphosphates. Phosphate can be hydrolyzed from the D3 and D5 positions in the inositol ring. Has low tyrosine-protein phosphatase activity; however, the relevance of such activity in vivo is unclear. Plays an important role in adipogenesis of mesenchymal stem cells (MSCs). Regulates the phosphorylation state of AKT1 by suppressing the phosphatidylinositol 3,4,5-trisphosphate (PIP3) level in MSCs and preadipocyte cells (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

In the inner ear of the early postnatal mouse, it is present in hair bundles in the cochlea and in the vestibule. Restricted to the hair bundles and not detected in any other cell type within the inner ear. Restricted to the basal region of the hair bundle (at protein level). {ECO:0000269PubMed:14534255}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0016791	phosphatase activity

Biological Process

GO:0002244	hematopoietic progenitor cell differentiation
GO:0006470	protein dephosphorylation
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0042472	inner ear morphogenesis
GO:0045598	regulation of fat cell differentiation
GO:0050885	neuromuscular process controlling balance
GO:0050910	detection of mechanical stimulus involved in sensory perception of sound
GO:0060116	vestibular receptor cell morphogenesis

Cellular Component

GO:0016021	integral component of membrane
GO:0032421	stereocilium bundle

Protein Structure and Domains

PDB ID

MGI:1096349

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR003961 Fibronectin, type III
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102
PF00041
PF01108

PRINTS

PR00700

PIRSF

SMART

SM00194
SM00404
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt