InnateDB Protein
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IDBP-189212.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Lcat
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Protein Name
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lecithin cholesterol acyltransferase
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Synonyms
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AI046659; D8Wsu61e;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000038232
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InnateDB Gene
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IDBG-189210 (Lcat)
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Protein Structure
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Function |
Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms (By similarity). Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines. {ECO:0000250, ECO:0000269PubMed:11809774, ECO:0000269PubMed:11893779, ECO:0000269PubMed:15654758, ECO:0000269PubMed:19065001}.
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Subcellular Localization |
Secreted. Note=Secreted into blood plasma. Produced in astrocytes and secreted into cerebral spinal fluid (CSF) (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Abundantly expressed in liver, brain and testis with highest levels in liver. In the brain, found in cerebellum, cerebral cortex, hippocampus and brain stem. Located to neurons and neuroglia. {ECO:0000269PubMed:19065001, ECO:0000269PubMed:2600083}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:96755
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InterPro |
IPR003386
Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase
IPR029058
Alpha/Beta hydrolase fold
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PFAM |
PF02450
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P16301
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PhosphoSite |
PhosphoSite-P16301
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
16816
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UniGene |
Mm.467489
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RefSeq |
NP_032516
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MGI ID |
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MGI Symbol |
Lcat
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OMIM |
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CCDS |
CCDS22622
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HPRD |
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IMGT |
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EMBL |
AC159265
AK149476
BC028861
J05154
X54095
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GenPept |
AAA39419
AAH28861
BAE28903
CAA38029
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