Mus musculus Protein: Lcat
Summary
InnateDB Protein IDBP-189212.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lcat
Protein Name lecithin cholesterol acyltransferase
Synonyms AI046659; D8Wsu61e;
Species Mus musculus
Ensembl Protein ENSMUSP00000038232
InnateDB Gene IDBG-189210 (Lcat)
Protein Structure
UniProt Annotation
Function Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms (By similarity). Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines. {ECO:0000250, ECO:0000269PubMed:11809774, ECO:0000269PubMed:11893779, ECO:0000269PubMed:15654758, ECO:0000269PubMed:19065001}.
Subcellular Localization Secreted. Note=Secreted into blood plasma. Produced in astrocytes and secreted into cerebral spinal fluid (CSF) (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Abundantly expressed in liver, brain and testis with highest levels in liver. In the brain, found in cerebellum, cerebral cortex, hippocampus and brain stem. Located to neurons and neuroglia. {ECO:0000269PubMed:19065001, ECO:0000269PubMed:2600083}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004607 phosphatidylcholine-sterol O-acyltransferase activity
GO:0005515 protein binding
GO:0008374 O-acyltransferase activity
GO:0034186 apolipoprotein A-I binding
Biological Process
GO:0006629 lipid metabolic process
GO:0006644 phospholipid metabolic process
GO:0006656 phosphatidylcholine biosynthetic process
GO:0008203 cholesterol metabolic process
GO:0030301 cholesterol transport
GO:0034372 very-low-density lipoprotein particle remodeling
GO:0034375 high-density lipoprotein particle remodeling
GO:0034435 cholesterol esterification
GO:0042158 lipoprotein biosynthetic process
GO:0042632 cholesterol homeostasis
GO:0043691 reverse cholesterol transport
GO:0090107 regulation of high-density lipoprotein particle assembly
Cellular Component
GO:0005615 extracellular space
GO:0034364 high-density lipoprotein particle
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:96755
InterPro IPR003386 Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase
IPR029058 Alpha/Beta hydrolase fold
PFAM PF02450
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P16301
PhosphoSite PhosphoSite-P16301
TrEMBL
UniProt Splice Variant
Entrez Gene 16816
UniGene Mm.467489
RefSeq NP_032516
MGI ID
MGI Symbol Lcat
OMIM
CCDS CCDS22622
HPRD
IMGT
EMBL AC159265 AK149476 BC028861 J05154 X54095
GenPept AAA39419 AAH28861 BAE28903 CAA38029