InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Lcat

Summary

InnateDB Gene

IDBG-189210.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lcat

Gene Name

lecithin cholesterol acyltransferase

Synonyms

AI046659; D8Wsu61e

Species

Mus musculus

Ensembl Gene

ENSMUSG00000035237

Encoded Proteins

IDBP-189212

lecithin cholesterol acyltransferase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000213398:
This gene encodes the extracellular cholesterol esterifying enzyme, lecithin-cholesterol acyltransferase. The esterification of cholesterol is required for cholesterol transport. Mutations in this gene have been found to cause fish-eye disease as well as LCAT deficiency. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:105939551-105943382

Strand

Reverse strand

Band

Transcripts

ENSMUST00000038896

ENSMUSP00000038232

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity
GO:0005515	protein binding
GO:0008374	O-acyltransferase activity
GO:0034186	apolipoprotein A-I binding

Biological Process

GO:0006629	lipid metabolic process
GO:0006644	phospholipid metabolic process
GO:0006656	phosphatidylcholine biosynthetic process
GO:0008203	cholesterol metabolic process
GO:0030301	cholesterol transport
GO:0034372	very-low-density lipoprotein particle remodeling
GO:0034375	high-density lipoprotein particle remodeling
GO:0034435	cholesterol esterification
GO:0042158	lipoprotein biosynthetic process
GO:0042632	cholesterol homeostasis
GO:0043691	reverse cholesterol transport
GO:0090107	regulation of high-density lipoprotein particle assembly