InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Syt1

Summary

InnateDB Protein

IDBP-189559.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Syt1

Protein Name

synaptotagmin I

Synonyms

AW124717; G630098F17Rik; SytI;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000063293

InnateDB Gene

IDBG-189557 (Syt1)

Protein Structure

UniProt Annotation

Function

May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.

Subcellular Localization

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass membrane protein. Cytoplasm. Note=Synaptic vesicles and chromaffin granules.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001786	phosphatidylserine binding
GO:0005215	transporter activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005544	calcium-dependent phospholipid binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0008022	protein C-terminus binding
GO:0017075	syntaxin-1 binding
GO:0030276	clathrin binding
GO:0042802	identical protein binding
GO:0048306	calcium-dependent protein binding
GO:0050750	low-density lipoprotein particle receptor binding

Biological Process

GO:0007269	neurotransmitter secretion
GO:0016079	synaptic vesicle exocytosis
GO:0031340	positive regulation of vesicle fusion
GO:0045956	positive regulation of calcium ion-dependent exocytosis
GO:0048278	vesicle docking
GO:0051592	response to calcium ion

Cellular Component

GO:0005886	plasma membrane
GO:0008021	synaptic vesicle
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030141	secretory granule
GO:0030672	synaptic vesicle membrane
GO:0031045	dense core granule
GO:0042584	chromaffin granule membrane
GO:0042734	presynaptic membrane
GO:0043005	neuron projection
GO:0060076	excitatory synapse