InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Syt1

Summary

InnateDB Gene

IDBG-189557.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Syt1

Gene Name

synaptotagmin I

Synonyms

AW124717; G630098F17Rik; SytI

Species

Mus musculus

Ensembl Gene

ENSMUSG00000035864

Encoded Proteins

IDBP-189559

synaptotagmin I

IDBP-271223

synaptotagmin I

IDBP-532135

synaptotagmin I

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000067715:
The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 [PubMed 11242035]).[supplied by OMIM, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:108497650-109010982

Strand

Reverse strand

Band

Transcripts

ENSMUST00000064054	ENSMUSP00000063293
ENSMUST00000105276	ENSMUSP00000100912
ENSMUST00000147593
ENSMUST00000156979	ENSMUSP00000116981
ENSMUST00000146618
ENSMUST00000126278

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000149	SNARE binding
GO:0001786	phosphatidylserine binding
GO:0005215	transporter activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005543	phospholipid binding
GO:0005544	calcium-dependent phospholipid binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0008022	protein C-terminus binding
GO:0017075	syntaxin-1 binding
GO:0019905	syntaxin binding
GO:0030276	clathrin binding
GO:0042802	identical protein binding
GO:0048306	calcium-dependent protein binding
GO:0050750	low-density lipoprotein particle receptor binding

Biological Process

GO:0007269	neurotransmitter secretion
GO:0016079	synaptic vesicle exocytosis
GO:0017158	regulation of calcium ion-dependent exocytosis
GO:0031340	positive regulation of vesicle fusion
GO:0045956	positive regulation of calcium ion-dependent exocytosis
GO:0048278	vesicle docking
GO:0051592	response to calcium ion

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0008021	synaptic vesicle
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030141	secretory granule
GO:0030672	synaptic vesicle membrane
GO:0031045	dense core granule
GO:0031201	SNARE complex
GO:0042584	chromaffin granule membrane
GO:0042734	presynaptic membrane
GO:0043005	neuron projection
GO:0043229	intracellular organelle
GO:0060076	excitatory synapse