InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Scnn1a

Summary

InnateDB Protein

IDBP-189819.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Scnn1a

Protein Name

sodium channel, nonvoltage-gated 1 alpha

Synonyms

ENaC; mENaC; SCNEA; Scnn1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000080164

InnateDB Gene

IDBG-189817 (Scnn1a)

Protein Structure

UniProt Annotation

Function

Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.

Subcellular Localization

Apical cell membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}. Cell projection, cilium {ECO:0000250}. Note=In multi-ciliated cells, located on cilia. In non-ciliated epithelial cells, restricted to apical surfaces (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in kidney and lung (at protein level). Also expressed in distal colon and, at low levels, in liver. {ECO:0000269PubMed:22207244}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005272	sodium channel activity
GO:0005515	protein binding
GO:0015280	ligand-gated sodium channel activity
GO:0050699	WW domain binding

Biological Process

GO:0006814	sodium ion transport
GO:0035725	sodium ion transmembrane transport
GO:0050878	regulation of body fluid levels
GO:0050891	multicellular organismal water homeostasis
GO:0050896	response to stimulus
GO:0050909	sensory perception of taste
GO:0055078	sodium ion homeostasis

Cellular Component

GO:0005829	cytosol
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0030864	cortical actin cytoskeleton
GO:0031514	motile cilium
GO:0034706	sodium channel complex
GO:0060170	ciliary membrane
GO:0070062	extracellular vesicular exosome