Mus musculus Gene: Scnn1a
Summary
InnateDB Gene IDBG-189817.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Scnn1a
Gene Name sodium channel, nonvoltage-gated 1 alpha
Synonyms ENaC; mENaC; SCNEA; Scnn1;
Species Mus musculus
Ensembl Gene ENSMUSG00000030340
Encoded Proteins
sodium channel, nonvoltage-gated 1 alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111319:
Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:125320659-125344943
Strand Forward strand
Band F3
Transcripts
ENSMUST00000081440 ENSMUSP00000080164
ENSMUST00000176442 ENSMUSP00000135336
ENSMUST00000176655 ENSMUSP00000135798
ENSMUST00000175966 ENSMUSP00000135551
ENSMUST00000176110 ENSMUSP00000134940
ENSMUST00000177329 ENSMUSP00000134929
ENSMUST00000176365 ENSMUSP00000135467
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005272 sodium channel activity
GO:0005515 protein binding
GO:0015280 ligand-gated sodium channel activity
GO:0050699 WW domain binding
Biological Process
GO:0006814 sodium ion transport
GO:0035725 sodium ion transmembrane transport
GO:0050878 regulation of body fluid levels
GO:0050891 multicellular organismal water homeostasis
GO:0050896 response to stimulus
GO:0050909 sensory perception of taste
GO:0055078 sodium ion homeostasis
Cellular Component
GO:0005829 cytosol
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0030864 cortical actin cytoskeleton
GO:0031514 motile cilium
GO:0034706 sodium channel complex
GO:0060170 ciliary membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Stimuli-sensing channels pathway
Ion channel transport pathway
Transmembrane transport of small molecules pathway
KEGG
Taste transduction pathway
Aldosterone-regulated sodium reabsorption pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Stimuli-sensing channels pathway
Ion channel transport pathway
KEGG
Taste transduction pathway
Aldosterone-regulated sodium reabsorption pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL H3BKP2 H3BKW1
UniProt Splice Variant
Entrez Gene 20276
UniGene Mm.144114
RefSeq NM_011324
OMIM
CCDS CCDS39641
HPRD
IMGT
MGI ID MGI:101782
MGI Symbol Scnn1a
EMBL AC140324
GenPept
RNA Seq Atlas 20276