InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Scnn1a

Summary

InnateDB Gene

IDBG-189817.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Scnn1a

Gene Name

sodium channel, nonvoltage-gated 1 alpha

Synonyms

ENaC; mENaC; SCNEA; Scnn1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030340

Encoded Proteins

IDBP-189819

sodium channel, nonvoltage-gated 1 alpha

IDBP-716406

IDBP-715815

IDBP-714249

IDBP-715087

IDBP-715831

IDBP-716569

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111319:
Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:125320659-125344943

Strand

Forward strand

Band

Transcripts

ENSMUST00000081440	ENSMUSP00000080164
ENSMUST00000176442	ENSMUSP00000135336
ENSMUST00000176655	ENSMUSP00000135798
ENSMUST00000175966	ENSMUSP00000135551
ENSMUST00000176110	ENSMUSP00000134940
ENSMUST00000177329	ENSMUSP00000134929
ENSMUST00000176365	ENSMUSP00000135467

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005272	sodium channel activity
GO:0005515	protein binding
GO:0015280	ligand-gated sodium channel activity
GO:0050699	WW domain binding

Biological Process

GO:0006814	sodium ion transport
GO:0035725	sodium ion transmembrane transport
GO:0050878	regulation of body fluid levels
GO:0050891	multicellular organismal water homeostasis
GO:0050896	response to stimulus
GO:0050909	sensory perception of taste
GO:0055078	sodium ion homeostasis

Cellular Component

GO:0005829	cytosol
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0030864	cortical actin cytoskeleton
GO:0031514	motile cilium
GO:0034706	sodium channel complex
GO:0060170	ciliary membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000111319

View Gene Order

ENSBTAG00000002631

Not yet available

Pathways

NETPATH

REACTOME

REACT_196640

Stimuli-sensing channels pathway

REACT_262350

Ion channel transport pathway

REACT_253400

Transmembrane transport of small molecules pathway

KEGG

mmu04742

Taste transduction pathway

mmu04960

Aldosterone-regulated sodium reabsorption pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_160189

Stimuli-sensing channels pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_25300

Ion channel transport pathway

KEGG

hsa04742

Taste transduction pathway

hsa04960

Aldosterone-regulated sodium reabsorption pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

H3BKP2 H3BKW1

UniProt Splice Variant

Entrez Gene

20276

UniGene

Mm.144114

RefSeq

NM_011324

OMIM

CCDS

CCDS39641

HPRD

IMGT

MGI ID

MGI:101782

MGI Symbol

Scnn1a

EMBL

AC140324

GenPept

RNA Seq Atlas

20276