InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tnfrsf1a

Summary

InnateDB Protein

IDBP-189846.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tnfrsf1a

Protein Name

tumor necrosis factor receptor superfamily, member 1a

Synonyms

CD120a; FPF; p55; p55-R; TNF-alphaR1; TNF-R; TNF-R-I; TNF-R1; TNF-R55; TNFalpha-R1; TNFAR; Tnfr-2; Tnfr1; TNFR60; TNFRI; TNFRp55;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032491

InnateDB Gene

IDBG-189844 (Tnfrsf1a)

Protein Structure

UniProt Annotation

Function

Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein. Golgi apparatus membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 159 interaction(s) predicted by orthology.

Experimentally validated
Total	52 [view]
Protein-Protein	50 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	159 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0005031	tumor necrosis factor-activated receptor activity
GO:0005515	protein binding
GO:0032403	protein complex binding
GO:0043120	tumor necrosis factor binding

Biological Process

GO:0001666	response to hypoxia
GO:0006693	prostaglandin metabolic process
GO:0006952	defense response
GO:0006954	inflammatory response
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009611	response to wounding
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0019221	cytokine-mediated signaling pathway
GO:0032496	response to lipopolysaccharide
GO:0032715	negative regulation of interleukin-6 production
GO:0032760	positive regulation of tumor necrosis factor production
GO:0033013	tetrapyrrole metabolic process
GO:0033160	positive regulation of protein import into nucleus, translocation
GO:0033209	tumor necrosis factor-mediated signaling pathway
GO:0042511	positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042742	defense response to bacterium
GO:0042981	regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043200	response to amino acid
GO:0043279	response to alkaloid
GO:0043525	positive regulation of neuron apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045471	response to ethanol
GO:0045766	positive regulation of angiogenesis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050728	negative regulation of inflammatory response
GO:0050729	positive regulation of inflammatory response
GO:0051291	protein heterooligomerization
GO:0071260	cellular response to mechanical stimulus
GO:0071392	cellular response to estradiol stimulus

Cellular Component

GO:0000139	Golgi membrane
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0043234	protein complex
GO:0043235	receptor complex
GO:0045121	membrane raft
GO:0045202	synapse