InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tnfrsf1a

Summary

InnateDB Gene

IDBG-189844.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tnfrsf1a

Gene Name

tumor necrosis factor receptor superfamily, member 1a

Synonyms

CD120a; FPF; p55; p55-R; TNF-alphaR1; TNF-R; TNF-R-I; TNF-R1; TNF-R55; TNFalpha-R1; TNFAR; Tnfr-2; Tnfr1; TNFR60; TNFRI; TNFRp55

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030341

Encoded Proteins

IDBP-189846

tumor necrosis factor receptor superfamily, member 1a

IDBP-540403

tumor necrosis factor receptor superfamily, member 1a

IDBP-541624

tumor necrosis factor receptor superfamily, member 1a

IDBP-536752

tumor necrosis factor receptor superfamily, member 1a

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21802165

Tnfrsf1a modulates nitric oxide production in peritoneal macrophages in response to Yersinia LPS stimulation through the Il6 and NFkB signalling pathway.

InnateDB Annotation from Orthologs

Summary

PMID 12753742

[Homo sapiens] Recruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation

PMID 19150425

[Homo sapiens] TNFR1 mediates TRAF2 phosphorylation and recruitment of the IKK complex

PMID 21802165

[Homo sapiens] TNFRSF1A modulates nitric oxide production in peritoneal macrophages in response to Yersinia LPS stimulation through the IL6 and NFkB signalling pathway. (Demonstrated in mouse)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000067182:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:125349362-125362484

Strand

Forward strand

Band

Transcripts

ENSMUST00000032491	ENSMUSP00000032491
ENSMUST00000131434
ENSMUST00000130257	ENSMUSP00000115991
ENSMUST00000125880	ENSMUSP00000121968
ENSMUST00000144524	ENSMUSP00000117470
ENSMUST00000134803

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 159 interaction(s) predicted by orthology.

Experimentally validated
Total	52 [view]
Protein-Protein	50 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	159 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0005031	tumor necrosis factor-activated receptor activity
GO:0005515	protein binding
GO:0032403	protein complex binding
GO:0043120	tumor necrosis factor binding

Biological Process

GO:0001666	response to hypoxia
GO:0006693	prostaglandin metabolic process
GO:0006952	defense response
GO:0006954	inflammatory response
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009611	response to wounding
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0019221	cytokine-mediated signaling pathway
GO:0032496	response to lipopolysaccharide
GO:0032715	negative regulation of interleukin-6 production
GO:0032760	positive regulation of tumor necrosis factor production
GO:0033013	tetrapyrrole metabolic process
GO:0033160	positive regulation of protein import into nucleus, translocation
GO:0033209	tumor necrosis factor-mediated signaling pathway
GO:0042511	positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042742	defense response to bacterium
GO:0042981	regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043200	response to amino acid
GO:0043279	response to alkaloid
GO:0043525	positive regulation of neuron apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045471	response to ethanol
GO:0045766	positive regulation of angiogenesis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050728	negative regulation of inflammatory response
GO:0050729	positive regulation of inflammatory response
GO:0051291	protein heterooligomerization
GO:0071260	cellular response to mechanical stimulus
GO:0071392	cellular response to estradiol stimulus

Cellular Component

GO:0000139	Golgi membrane
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0043234	protein complex
GO:0043235	receptor complex
GO:0045121	membrane raft
GO:0045202	synapse