Mus musculus Gene: Tnfrsf1a
Summary
InnateDB Gene IDBG-189844.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tnfrsf1a
Gene Name tumor necrosis factor receptor superfamily, member 1a
Synonyms CD120a; FPF; p55; p55-R; TNF-alphaR1; TNF-R; TNF-R-I; TNF-R1; TNF-R55; TNFalpha-R1; TNFAR; Tnfr-2; Tnfr1; TNFR60; TNFRI; TNFRp55;
Species Mus musculus
Ensembl Gene ENSMUSG00000030341
Encoded Proteins
tumor necrosis factor receptor superfamily, member 1a
tumor necrosis factor receptor superfamily, member 1a
tumor necrosis factor receptor superfamily, member 1a
tumor necrosis factor receptor superfamily, member 1a
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Tnfrsf1a modulates nitric oxide production in peritoneal macrophages in response to Yersinia LPS stimulation through the Il6 and NFkB signalling pathway.
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] Recruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation
[Homo sapiens] TNFR1 mediates TRAF2 phosphorylation and recruitment of the IKK complex
[Homo sapiens] TNFRSF1A modulates nitric oxide production in peritoneal macrophages in response to Yersinia LPS stimulation through the IL6 and NFkB signalling pathway. (Demonstrated in mouse)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000067182:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:125349362-125362484
Strand Forward strand
Band F3
Transcripts
ENSMUST00000032491 ENSMUSP00000032491
ENSMUST00000131434
ENSMUST00000130257 ENSMUSP00000115991
ENSMUST00000125880 ENSMUSP00000121968
ENSMUST00000144524 ENSMUSP00000117470
ENSMUST00000134803
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 159 interaction(s) predicted by orthology.
Experimentally validated
Total 52 [view]
Protein-Protein 50 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 159 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0005031 tumor necrosis factor-activated receptor activity
GO:0005515 protein binding
GO:0032403 protein complex binding
GO:0043120 tumor necrosis factor binding
Biological Process
GO:0001666 response to hypoxia
GO:0006693 prostaglandin metabolic process
GO:0006952 defense response
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009611 response to wounding
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0019221 cytokine-mediated signaling pathway
GO:0032496 response to lipopolysaccharide
GO:0032715 negative regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0033013 tetrapyrrole metabolic process
GO:0033160 positive regulation of protein import into nucleus, translocation
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0042511 positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042742 defense response to bacterium
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043200 response to amino acid
GO:0043279 response to alkaloid
GO:0043525 positive regulation of neuron apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0045471 response to ethanol
GO:0045766 positive regulation of angiogenesis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050728 negative regulation of inflammatory response
GO:0050729 positive regulation of inflammatory response
GO:0051291 protein heterooligomerization
GO:0071260 cellular response to mechanical stimulus
GO:0071392 cellular response to estradiol stimulus
Cellular Component
GO:0000139 Golgi membrane
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0030424 axon
GO:0043234 protein complex
GO:0043235 receptor complex
GO:0045121 membrane raft
GO:0045202 synapse
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Apoptosis pathway
TNF signaling pathway
Death Receptor Signalling pathway
Extrinsic Pathway for Apoptosis pathway
KEGG
MAPK signaling pathway pathway
Cytokine-cytokine receptor interaction pathway
Apoptosis pathway
Osteoclast differentiation pathway
Adipocytokine signaling pathway pathway
Alzheimer's disease pathway
Amyotrophic lateral sclerosis (ALS) pathway
Chagas disease (American trypanosomiasis) pathway
Toxoplasmosis pathway
Hepatitis C pathway
INOH
TNFR1 signaling pathway pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
TNFalpha pathway
REACTOME
Extrinsic Pathway for Apoptosis pathway
Apoptosis pathway
TNF signaling pathway
Death Receptor Signalling pathway
KEGG
MAPK signaling pathway pathway
Cytokine-cytokine receptor interaction pathway
Apoptosis pathway
Osteoclast differentiation pathway
Adipocytokine signaling pathway pathway
Alzheimer's disease pathway
Amyotrophic lateral sclerosis (ALS) pathway
Chagas disease (American trypanosomiasis) pathway
Toxoplasmosis pathway
Hepatitis C pathway
INOH
TNFR1 signaling pathway pathway
PID BIOCARTA
Nf-kb signaling pathway [Biocarta view]
Keratinocyte differentiation [Biocarta view]
Tnfr1 signaling pathway [Biocarta view]
Hiv-1 nef: negative effector of fas and tnf [Biocarta view]
Tnf/stress related signaling [Biocarta view]
Sodd/tnfr1 signaling pathway [Biocarta view]
Ceramide signaling pathway [Biocarta view]
PID NCI
Ceramide signaling pathway
Caspase Cascade in Apoptosis
TNF receptor signaling pathway
Signaling events mediated by HDAC Class I
Canonical NF-kappaB pathway
HIV-1 Nef: Negative effector of Fas and TNF-alpha
Cross-References
SwissProt
TrEMBL F7A4X5
UniProt Splice Variant
Entrez Gene 21937
UniGene Mm.1258 Mm.452214
RefSeq NM_011609
OMIM
CCDS CCDS20550
HPRD
IMGT
MGI ID MGI:1314884
MGI Symbol Tnfrsf1a
EMBL AC140324
GenPept
RNA Seq Atlas 21937