InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trem2

Summary

InnateDB Protein

IDBP-189873.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trem2

Protein Name

triggering receptor expressed on myeloid cells 2

Synonyms

TREM-2; Trem2a; Trem2b; Trem2c;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000024791

InnateDB Gene

IDBG-189871 (Trem2)

Protein Structure

UniProt Annotation

Function

May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. {ECO:0000269PubMed:11241283}.

Subcellular Localization

Isoform 1: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.Isoform 2: Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed at higher levels in the CNS, heart and lung than in lymph nodes or in other non-lymphoid tissues such as kidney, liver and testis. In the CNS not all microglia express TREM2. Brain regions with an incomplete blood-brain barrier had the lowest percentages of TREM2 expressing microglia, whereas the lateral entorhinal and cingulate cortex had the highest percentages. {ECO:0000269PubMed:11241283, ECO:0000269PubMed:12472885}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001530	lipopolysaccharide binding
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding
GO:0097110	scaffold protein binding

Biological Process

GO:0002588	positive regulation of antigen processing and presentation of peptide antigen via MHC class II
GO:0007165	signal transduction
GO:0045087	innate immune response (InnateDB)
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050850	positive regulation of calcium-mediated signaling
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0097028	dendritic cell differentiation
GO:1903078	positive regulation of protein localization to plasma membrane
GO:1903082	positive regulation of C-C chemokine receptor CCR7 signaling pathway
GO:2000350	positive regulation of CD40 signaling pathway