InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Plscr1

Summary

InnateDB Protein

IDBP-191071.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plscr1

Protein Name

phospholipid scramblase 1

Synonyms

MmTRA1a; MmTRA1b; Nor1; Tra1; Tra1a; Tra1b; Tras1; Tras2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000091318

InnateDB Gene

IDBG-191069 (Plscr1)

Protein Structure

UniProt Annotation

Function

May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. {ECO:0000269PubMed:12010804}.May play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes. May contribute to cytokine-regulated cell proliferation and differentiation. {ECO:0000269PubMed:12010804}.

Subcellular Localization

Membrane {ECO:0000250}; Single-pass type II membrane protein. Membrane; Lipid-anchor {ECO:0000250}; Cytoplasmic side. Nucleus {ECO:0000250}.

Disease Associations

Note=Participates in a chromosomal translocation that produces MMTRA1A which is leukemogenic to syngenic SL mice and athymic nude mice.

Tissue Specificity

Highly expressed in kidney, lung, liver and bone marrow, slightly in spleen, heart and macrophage.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 75 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	75 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0005154	epidermal growth factor receptor binding
GO:0005509	calcium ion binding
GO:0017124	SH3 domain binding
GO:0017128	phospholipid scramblase activity
GO:0042609	CD4 receptor binding

Biological Process

GO:0006659	phosphatidylserine biosynthetic process
GO:0006953	acute-phase response
GO:0017121	phospholipid scrambling
GO:0030099	myeloid cell differentiation
GO:0032091	negative regulation of protein binding
GO:0033003	regulation of mast cell activation
GO:0035455	response to interferon-alpha
GO:0043065	positive regulation of apoptotic process
GO:0045071	negative regulation of viral genome replication
GO:0045087	innate immune response (InnateDB)
GO:0045089	positive regulation of innate immune response
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051607	defense response to virus
GO:0060368	regulation of Fc receptor mediated stimulatory signaling pathway
GO:0070782	phosphatidylserine exposure on apoptotic cell surface
GO:0071222	cellular response to lipopolysaccharide
GO:0071345	cellular response to cytokine stimulus
GO:0097193	intrinsic apoptotic signaling pathway
GO:1902231	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:2000373	positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0031012	extracellular matrix
GO:0045121	membrane raft