InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dhodh

Summary

InnateDB Protein

IDBP-191277.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dhodh

Protein Name

dihydroorotate dehydrogenase

Synonyms

2810417D19Rik; AI834883;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000070303

InnateDB Gene

IDBG-191275 (Dhodh)

Protein Structure

UniProt Annotation

Function

Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004152	dihydroorotate dehydrogenase activity
GO:0004158	dihydroorotate oxidase activity
GO:0008144	drug binding
GO:0010181	FMN binding
GO:0048039	ubiquinone binding

Biological Process

GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process
GO:0006222	UMP biosynthetic process
GO:0007565	female pregnancy
GO:0007595	lactation
GO:0014070	response to organic cyclic compound
GO:0031000	response to caffeine
GO:0042493	response to drug
GO:0042594	response to starvation
GO:0043065	positive regulation of apoptotic process
GO:0044205	'de novo' UMP biosynthetic process
GO:0055114	oxidation-reduction process
GO:0090140	regulation of mitochondrial fission