Version 5.4
Mus musculus Gene: Dhodh
Summary
InnateDB Gene IDBG-191275.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dhodh
Gene Name dihydroorotate dehydrogenase
Synonyms 2810417D19Rik; AI834883
Species Mus musculus
Ensembl Gene ENSMUSG00000031730
Encoded Proteins
IDBP-191277
dihydroorotate dehydrogenase
IDBP-535653
dihydroorotate dehydrogenase
IDBP-539766
dihydroorotate dehydrogenase
IDBP-532285
dihydroorotate dehydrogenase
IDBP-536934
dihydroorotate dehydrogenase
IDBP-536154
dihydroorotate dehydrogenase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102967:
The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:109591343-109608673
Strand Reverse strand
Band D3
Transcripts
ENSMUST00000069058 ENSMUSP00000070303
ENSMUST00000133353 ENSMUSP00000114190
ENSMUST00000125222
ENSMUST00000123605 ENSMUSP00000115934
ENSMUST00000143900 ENSMUSP00000117980
ENSMUST00000142106
ENSMUST00000124138
ENSMUST00000125779
ENSMUST00000150804 ENSMUSP00000115549
ENSMUST00000146064
ENSMUST00000131107
ENSMUST00000128350 ENSMUSP00000118612
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004152 dihydroorotate dehydrogenase activity
GO:0004158 dihydroorotate oxidase activity
GO:0008144 drug binding
GO:0010181 FMN binding
GO:0048039 ubiquinone binding
Biological Process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006222 UMP biosynthetic process
GO:0007565 female pregnancy
GO:0007595 lactation
GO:0014070 response to organic cyclic compound
GO:0031000 response to caffeine
GO:0042493 response to drug
GO:0042594 response to starvation
GO:0043065 positive regulation of apoptotic process
GO:0044205 'de novo' UMP biosynthetic process
GO:0055114 oxidation-reduction process
GO:0090140 regulation of mitochondrial fission
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043025 neuronal cell body
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000102967
View Gene Order
ENSBTAG00000019887
Not yet available
Pathways
NETPATH
REACTOME
REACT_238763
Pyrimidine biosynthesis pathway
REACT_236186
Pyrimidine metabolism pathway
REACT_188937
Metabolism pathway
REACT_245662
Metabolism of nucleotides pathway
KEGG
mmu00240
Pyrimidine metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_21376
Pyrimidine biosynthesis pathway
REACT_1698
Metabolism of nucleotides pathway
REACT_957
Pyrimidine metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00240
Pyrimidine metabolism pathway
INOH
INOH website
Pyrimidine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.23894 Mm.411062
RefSeq NM_020046
OMIM
CCDS CCDS40471
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca