Mus musculus Protein: Trpc1
Summary
InnateDB Protein IDBP-191541.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Trpc1
Protein Name transient receptor potential cation channel, subfamily C, member 1
Synonyms Mtrp1; Trp1; Trrp1;
Species Mus musculus
Ensembl Protein ENSMUSP00000057640
InnateDB Gene IDBG-191539 (Trpc1)
Protein Structure
UniProt Annotation
Function Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005515 protein binding
Biological Process
GO:0006811 ion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:109528
InterPro IPR002110 Ankyrin repeat
IPR002153 Transient receptor potential channel, canonical
IPR004729 Transient receptor potential channel
IPR005457 Transient receptor potential channel, canonical 1
IPR005821 Ion transport domain
IPR013555 Transient receptor ion channel domain
IPR020683 Ankyrin repeat-containing domain
PFAM PF00023
PF13606
PF00520
PF08344
PF11929
PF12796
PRINTS PR01415
PR01097
PR01642
PIRSF
SMART SM00248
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-Q61056
TrEMBL B7ZMP6
UniProt Splice Variant
Entrez Gene 22063
UniGene
RefSeq XP_006511117
MGI ID
MGI Symbol Trpc1
OMIM
CCDS
HPRD
IMGT
EMBL BC144726 CH466560
GenPept AAI44727 EDL20941