InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atr

Summary

InnateDB Protein

IDBP-191648.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atr

Protein Name

ataxia telangiectasia and Rad3 related

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034980

InnateDB Gene

IDBG-191646 (Atr)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 88 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	88 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0032405	MutLalpha complex binding
GO:0032407	MutSalpha complex binding

Biological Process

GO:0000077	DNA damage checkpoint
GO:0006281	DNA repair
GO:0006468	protein phosphorylation
GO:0006974	cellular response to DNA damage stimulus
GO:0008156	negative regulation of DNA replication
GO:0018105	peptidyl-serine phosphorylation
GO:0034644	cellular response to UV
GO:0042493	response to drug
GO:0043393	regulation of protein binding
GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0046777	protein autophosphorylation
GO:0071480	cellular response to gamma radiation
GO:0090399	replicative senescence

Cellular Component

GO:0001741	XY body
GO:0005634	nucleus
GO:0016605	PML body

Protein Structure and Domains

PDB ID

MGI:108028

InterPro

IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR003151 PIK-related kinase, FAT
IPR003152 PIK-related kinase, FATC
IPR011009 Protein kinase-like domain
IPR012993 UME
IPR014009 PIK-related kinase
IPR016024 Armadillo-type fold
IPR021133 HEAT, type 2

PFAM

PF00454
PF02259
PF02260
PF08064

PRINTS

PIRSF

SMART

SM00146
SM00802

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite