Mus musculus Gene: Atr
Summary
InnateDB Gene IDBG-191646.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Atr
Gene Name ataxia telangiectasia and Rad3 related
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000032409
Encoded Proteins
ataxia telangiectasia and Rad3 related
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175054:
The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:95857597-95951644
Strand Forward strand
Band E3.3
Transcripts
ENSMUST00000034980 ENSMUSP00000034980
ENSMUST00000187356
ENSMUST00000185473
ENSMUST00000189602
ENSMUST00000186061
ENSMUST00000191269
ENSMUST00000186127
ENSMUST00000188164
ENSMUST00000190644
ENSMUST00000186997
ENSMUST00000188088
ENSMUST00000186524
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 88 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 88 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005488 binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0032405 MutLalpha complex binding
GO:0032407 MutSalpha complex binding
Biological Process
GO:0000077 DNA damage checkpoint
GO:0006281 DNA repair
GO:0006468 protein phosphorylation
GO:0006974 cellular response to DNA damage stimulus
GO:0008156 negative regulation of DNA replication
GO:0018105 peptidyl-serine phosphorylation
GO:0034644 cellular response to UV
GO:0042493 response to drug
GO:0043393 regulation of protein binding
GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0046777 protein autophosphorylation
GO:0071480 cellular response to gamma radiation
GO:0090399 replicative senescence
Cellular Component
GO:0001741 XY body
GO:0005634 nucleus
GO:0016605 PML body
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Cell cycle pathway
p53 signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Cellular responses to stress pathway
Regulation of HSF1-mediated heat shock response pathway
Meiotic synapsis pathway
G2/M DNA damage checkpoint pathway
G2/M Checkpoints pathway
Cell Cycle pathway
Fanconi Anemia pathway pathway
Cellular response to heat stress pathway
Regulation of the Fanconi anemia pathway pathway
Activation of ATR in response to replication stress pathway
Meiosis pathway
DNA Repair pathway
Cell Cycle Checkpoints pathway
KEGG
Cell cycle pathway
p53 signaling pathway pathway
INOH
PID BIOCARTA
Atm signaling pathway [Biocarta view]
Cell cycle: g1/s check point [Biocarta view]
Cell cycle: g2/m checkpoint [Biocarta view]
Regulation of cell cycle progression by plk3 [Biocarta view]
Role of brca1 brca2 and atr in cancer susceptibility [Biocarta view]
PID NCI
Fanconi anemia pathway
p53 pathway
Signaling events mediated by TCPTP
Circadian rhythm pathway
BARD1 signaling events
ATR signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_019864 XM_006511184 XM_006511186 XM_006511187
OMIM
CCDS CCDS52890
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas