InnateDB Protein
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IDBP-191658.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Elk4
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Protein Name
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ELK4, member of ETS oncogene family
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Synonyms
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2310011G17Rik; A130026I01Rik; BB162516; SAP-1; Sap1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000083743
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InnateDB Gene
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IDBG-191654 (Elk4)
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Protein Structure
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Function |
Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
Lung and liver.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
0
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
Accession |
GO Term |
GO:0000981
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sequence-specific DNA binding RNA polymerase II transcription factor activity
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GO:0003682
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chromatin binding
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0005515
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protein binding
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GO:0043565
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sequence-specific DNA binding
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0006357
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regulation of transcription from RNA polymerase II promoter
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GO:0006366
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transcription from RNA polymerase II promoter
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GO:0030154
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cell differentiation
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GO:0070932
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histone H3 deacetylation
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Cellular Component |
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PDB ID |
MGI:102853
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InterPro |
IPR000418
Ets domain
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PFAM |
PF00178
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PRINTS |
PR00454
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PIRSF |
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SMART |
SM00413
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TIGRFAMs |
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Modification |
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SwissProt |
P41158
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PhosphoSite |
PhosphoSite-P41158
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TrEMBL |
Q8C6Q0
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UniProt Splice Variant |
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Entrez Gene |
13714
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UniGene |
Mm.488735
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RefSeq |
NP_031949
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MGI ID |
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MGI Symbol |
Elk4
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OMIM |
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CCDS |
CCDS35704
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HPRD |
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IMGT |
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EMBL |
AC107837
AK054075
BC144844
BC145795
CH466520
Z36885
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GenPept |
AAI44845
AAI45796
BAC35647
CAA85358
EDL39692
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