InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cpsf6

Summary

InnateDB Protein

IDBP-191784.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cpsf6

Protein Name

cleavage and polyadenylation specific factor 6

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000068408

InnateDB Gene

IDBG-191782 (Cpsf6)

Protein Structure

UniProt Annotation

Function

Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3'-processing. Involved in association with NUDT21/CPSF5 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. CPSF6 binds to cleavage and polyadenylation RNA substrates and promotes RNA looping (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Note=In punctate subnuclear structures localized adjacent to nuclear speckles, called paraspeckles. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 56 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	56 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding