InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Aldh1a3

Summary

InnateDB Protein

IDBP-191848.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aldh1a3

Protein Name

aldehyde dehydrogenase family 1, subfamily A3

Synonyms

ALDH6; RALDH3; V1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000015278

InnateDB Gene

IDBG-191846 (Aldh1a3)

Protein Structure

UniProt Annotation

Function

Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system. {ECO:0000269PubMed:10906479, ECO:0000269PubMed:11013254, ECO:0000269PubMed:11025231, ECO:0000269PubMed:11044606}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:11013254}.

Disease Associations

Tissue Specificity

Ventral retina. {ECO:0000269PubMed:10906479, ECO:0000269PubMed:11013254, ECO:0000269PubMed:11025231, ECO:0000269PubMed:11044606}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004028	3-chloroallyl aldehyde dehydrogenase activity
GO:0004029	aldehyde dehydrogenase (NAD) activity
GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity
GO:0016491	oxidoreductase activity
GO:0042803	protein homodimerization activity
GO:0070324	thyroid hormone binding
GO:0070403	NAD+ binding

Biological Process

GO:0002072	optic cup morphogenesis involved in camera-type eye development
GO:0002138	retinoic acid biosynthetic process
GO:0007626	locomotory behavior
GO:0008152	metabolic process
GO:0021768	nucleus accumbens development
GO:0031076	embryonic camera-type eye development
GO:0042472	inner ear morphogenesis
GO:0042572	retinol metabolic process
GO:0042573	retinoic acid metabolic process
GO:0042574	retinal metabolic process
GO:0043065	positive regulation of apoptotic process
GO:0048048	embryonic eye morphogenesis
GO:0048386	positive regulation of retinoic acid receptor signaling pathway
GO:0050885	neuromuscular process controlling balance
GO:0055114	oxidation-reduction process
GO:0060013	righting reflex
GO:0060166	olfactory pit development
GO:0060324	face development