Mus musculus Protein: Uhrf1 | |||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||||||||
InnateDB Protein | IDBP-191988.6 | ||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||
Gene Symbol | Uhrf1 | ||||||||||||||||||||||||
Protein Name | ubiquitin-like, containing PHD and RING finger domains, 1 | ||||||||||||||||||||||||
Synonyms | AL022808; ICBP90; Np95; RNF106; | ||||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||||
Ensembl Protein | ENSMUSP00000001258 | ||||||||||||||||||||||||
InnateDB Gene | IDBG-191986 (Uhrf1) | ||||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||||
Function | Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD- type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. May be involved in DNA repair. {ECO:0000269PubMed:12058012, ECO:0000269PubMed:12084726, ECO:0000269PubMed:14993289, ECO:0000269PubMed:15361834, ECO:0000269PubMed:17673620, ECO:0000269PubMed:17994007, ECO:0000269PubMed:21268065, ECO:0000269PubMed:21489993}. | ||||||||||||||||||||||||
Subcellular Localization | Nucleus {ECO:0000255PROSITE- ProRule:PRU00358, ECO:0000269PubMed:10984098, ECO:0000269PubMed:11161719, ECO:0000269PubMed:14993289, ECO:0000269PubMed:17994007, ECO:0000269PubMed:21489993, ECO:0000269PubMed:8634372}. Note=Localizes to replication foci. Enriched in pericentric heterochromatin. Also localizes to euchromatic regions. | ||||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||||
Tissue Specificity | Expressed in thymus, testis, spleen and lung. Within testis, expressed in almost all cells except elongated spermatids. {ECO:0000269PubMed:10984098, ECO:0000269PubMed:9880673}. | ||||||||||||||||||||||||
Comments | |||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
|
||||||||||||||||||||||||
Gene Ontology | |||||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||||
Biological Process |
|
||||||||||||||||||||||||
Cellular Component |
|
||||||||||||||||||||||||
Protein Structure and Domains | |||||||||||||||||||||||||
PDB ID | MGI:1338889 | ||||||||||||||||||||||||
InterPro |
IPR000626
Ubiquitin-like IPR001841 Zinc finger, RING-type IPR001965 Zinc finger, PHD-type IPR003105 SRA-YDG IPR011011 Zinc finger, FYVE/PHD-type IPR019787 Zinc finger, PHD-finger IPR021991 Domain of unknown function DUF3590 IPR022617 Rad60/SUMO-like domain IPR029071 Ubiquitin-related domain |
||||||||||||||||||||||||
PFAM |
PF00240
PF14560 PF13639 PF14634 PF02182 PF00628 PF12148 PF11976 |
||||||||||||||||||||||||
PRINTS | |||||||||||||||||||||||||
PIRSF | |||||||||||||||||||||||||
SMART |
SM00213
SM00184 SM00249 SM00466 |
||||||||||||||||||||||||
TIGRFAMs | |||||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||||
Modification | |||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||
SwissProt | Q8VDF2 | ||||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q8VDF2 | ||||||||||||||||||||||||
TrEMBL | E9Q5Y5 | ||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||
Entrez Gene | 18140 | ||||||||||||||||||||||||
UniGene | Mm.42196 | ||||||||||||||||||||||||
RefSeq | NP_035061 | ||||||||||||||||||||||||
MGI ID | 3FDE | ||||||||||||||||||||||||
MGI Symbol | Uhrf1 | ||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||
CCDS | CCDS28903 | ||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||
EMBL | AB066246 AC026385 AF274046 AK075819 AK143688 AK145376 AK145543 AK146951 AK147046 AK150489 AK151701 AK151837 AK152930 AK153083 BC022167 D87908 | ||||||||||||||||||||||||
GenPept | AAH22167 AAK55743 BAA74579 BAB79496 BAC35985 BAE25499 BAE26398 BAE26496 BAE27560 BAE27632 BAE29605 BAE30624 BAE30730 BAE31605 BAE31708 | ||||||||||||||||||||||||