InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ren1

Summary

InnateDB Protein

IDBP-192846.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ren1

Protein Name

renin 1 structural

Synonyms

D19352; Ren; Ren-1; Ren-2; Ren-A; Ren-B; Ren1c; Ren1d; Rn-1; Rn-2; Rnr;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000092135

InnateDB Gene

IDBG-192844 (Ren1)

Protein Structure

UniProt Annotation

Function

Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.

Subcellular Localization

Secreted {ECO:0000250}. Membrane {ECO:0000250}. Note=Associated to membranes via binding to ATP6AP2. {ECO:0000250}.

Disease Associations

Tissue Specificity

Kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004175	endopeptidase activity
GO:0004190	aspartic-type endopeptidase activity
GO:0005102	receptor binding
GO:0005159	insulin-like growth factor receptor binding
GO:0008233	peptidase activity

Biological Process

GO:0001822	kidney development
GO:0001823	mesonephros development
GO:0002003	angiotensin maturation
GO:0002016	regulation of blood volume by renin-angiotensin
GO:0002018	renin-angiotensin regulation of aldosterone production
GO:0006508	proteolysis
GO:0008584	male gonad development
GO:0009755	hormone-mediated signaling pathway
GO:0010033	response to organic substance
GO:0032496	response to lipopolysaccharide
GO:0035690	cellular response to drug
GO:0035902	response to immobilization stress
GO:0042493	response to drug
GO:0042756	drinking behavior
GO:0043408	regulation of MAPK cascade
GO:0048469	cell maturation
GO:0050435	beta-amyloid metabolic process
GO:0051591	response to cAMP
GO:0070305	response to cGMP