Version 5.4
Mus musculus Gene: Ren1
Summary
InnateDB Gene IDBG-192844.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ren1
Gene Name renin 1 structural
Synonyms D19352; Ren; Ren-1; Ren-2; Ren-A; Ren-B; Ren1c; Ren1d; Rn-1; Rn-2; Rnr
Species Mus musculus
Ensembl Gene ENSMUSG00000070645
Encoded Proteins
IDBP-192846
renin 1 structural
IDBP-256325
renin 1 structural
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143839:
Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:133350510-133360325
Strand Forward strand
Band E4
Transcripts
ENSMUST00000094556 ENSMUSP00000092135
ENSMUST00000112287 ENSMUSP00000107906
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004175 endopeptidase activity
GO:0004190 aspartic-type endopeptidase activity
GO:0005102 receptor binding
GO:0005159 insulin-like growth factor receptor binding
GO:0008233 peptidase activity
Biological Process
GO:0001822 kidney development
GO:0001823 mesonephros development
GO:0002003 angiotensin maturation
GO:0002016 regulation of blood volume by renin-angiotensin
GO:0002018 renin-angiotensin regulation of aldosterone production
GO:0006508 proteolysis
GO:0008584 male gonad development
GO:0009755 hormone-mediated signaling pathway
GO:0010033 response to organic substance
GO:0032496 response to lipopolysaccharide
GO:0035690 cellular response to drug
GO:0035902 response to immobilization stress
GO:0042493 response to drug
GO:0042756 drinking behavior
GO:0043408 regulation of MAPK cascade
GO:0048469 cell maturation
GO:0050435 beta-amyloid metabolic process
GO:0051591 response to cAMP
GO:0070305 response to cGMP
Cellular Component
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000143839
View Gene Order
ENSBTAG00000021333
Not yet available
Pathways
NETPATH
REACTOME
REACT_247926
Metabolism of proteins pathway
REACT_206913
Peptide hormone metabolism pathway
REACT_196539
Metabolism of Angiotensinogen to Angiotensins pathway
KEGG
mmu04614
Renin-angiotensin system pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_147707
Metabolism of Angiotensinogen to Angiotensins pathway
REACT_17015
Metabolism of proteins pathway
REACT_160078
Peptide hormone metabolism pathway
KEGG
hsa04614
Renin-angiotensin system pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q9R259
UniProt Splice Variant
Entrez Gene 19702
UniGene
RefSeq NM_031192 NM_031193 XM_006497265 XM_006543567 XM_006543568
OMIM
CCDS CCDS15295
HPRD
IMGT
MGI ID MGI:97898
MGI Symbol Ren1
EMBL AC068906 AF117821
GenPept AAD26253
RNA Seq Atlas 102643057 19701 19702

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca