Version 5.4
Mus musculus Protein: St8sia2
Summary
InnateDB Protein IDBP-192864.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol St8sia2
Protein Name ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
Synonyms AI323367; Siat8b; ST8SiaII; STX;
Species Mus musculus
Ensembl Protein ENSMUSP00000026896
InnateDB Gene IDBG-192862 (St8sia2)
Protein Structure
UniProt Annotation
Function May transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic acid of N-linked oligosaccharides of glycoproteins and may be involved in PSA (polysialic acid) expression. {ECO:0000250}.
Subcellular Localization Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
GO:0008373 sialyltransferase activity
Biological Process
GO:0001574 ganglioside biosynthetic process
GO:0006486 protein glycosylation
GO:0006491 N-glycan processing
GO:0009311 oligosaccharide metabolic process
GO:0097503 sialylation
Cellular Component
GO:0005769 early endosome
GO:0030173 integral component of Golgi membrane
GO:0055037 recycling endosome
Protein Structure and Domains
PDB ID MGI:106020
InterPro IPR001675 Glycosyl transferase, family 29
IPR012163 Sialyltransferase
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like
PFAM PF00777
PRINTS
PIRSF PIRSF005557
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O35696
PhosphoSite PhosphoSite-O35696
TrEMBL
UniProt Splice Variant
Entrez Gene 20450
UniGene Mm.4954
RefSeq NP_033207
MGI ID
MGI Symbol St8sia2
OMIM
CCDS CCDS21365
HPRD
IMGT
EMBL BC096546 CH466543 X83562 X99646 X99647 X99648 X99649 X99650 X99651
GenPept AAH96546 CAA58548 CAA67965 EDL07123

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca