Mus musculus Protein: Chit1 | |||||||||||
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Summary | |||||||||||
InnateDB Protein | IDBP-193351.6 | ||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
Gene Symbol | Chit1 | ||||||||||
Protein Name | chitinase 1 (chitotriosidase) | ||||||||||
Synonyms | 2300002L19Rik; | ||||||||||
Species | Mus musculus | ||||||||||
Ensembl Protein | ENSMUSP00000083666 | ||||||||||
InnateDB Gene | IDBG-193347 (Chit1) | ||||||||||
Protein Structure | |||||||||||
UniProt Annotation | |||||||||||
Function | Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens (By similarity). {ECO:0000250}. | ||||||||||
Subcellular Localization | Secreted {ECO:0000269PubMed:16005164}. Lysosome {ECO:0000250}. Note=A small proportion is lysosomal. {ECO:0000250}. | ||||||||||
Disease Associations | |||||||||||
Tissue Specificity | Highly expressed in tongue, stomach, kidney, brain, skin, testis, and bone marrow. Low level of expression was found in lung, heart, spleen, small intestine, and liver. Not detectable in pancreas, salivary gland, large intestine, uterus, or peripheral blood mononuclear cells (PBMC). {ECO:0000269PubMed:15923370, ECO:0000269PubMed:16005164}. | ||||||||||
Comments | |||||||||||
Interactions | |||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||
PDB ID | MGI:1919134 | ||||||||||
InterPro |
IPR001223
Glycoside hydrolase, family 18, catalytic domain IPR002557 Chitin binding domain IPR011583 Chitinase II IPR017853 Glycoside hydrolase, superfamily IPR029070 Chitinase insertion domain |
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PFAM |
PF00704
PF01607 |
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PRINTS | |||||||||||
PIRSF | |||||||||||
SMART |
SM00494
SM00636 |
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TIGRFAMs | |||||||||||
Post-translational Modifications | |||||||||||
Modification | |||||||||||
Cross-References | |||||||||||
SwissProt | Q9D7Q1 | ||||||||||
PhosphoSite | PhosphoSite- | ||||||||||
TrEMBL | B2RS82 | ||||||||||
UniProt Splice Variant | |||||||||||
Entrez Gene | 71884 | ||||||||||
UniGene | Mm.328268 | ||||||||||
RefSeq | |||||||||||
MGI ID | |||||||||||
MGI Symbol | Chit1 | ||||||||||
OMIM | |||||||||||
CCDS | CCDS15304 | ||||||||||
HPRD | |||||||||||
IMGT | |||||||||||
EMBL | AK009012 AY458654 AY536287 BC138765 CH466520 | ||||||||||
GenPept | AAI38766 AAR14312 AAS47832 BAB26025 EDL39629 | ||||||||||