Version 5.4
Mus musculus Gene: Chit1
Summary
InnateDB Gene IDBG-193347.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Chit1
Gene Name chitinase 1 (chitotriosidase)
Synonyms 2300002L19Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000026450
Encoded Proteins
IDBP-193351
chitinase 1 (chitotriosidase)
IDBP-533746
chitinase 1 (chitotriosidase)
IDBP-533660
chitinase 1 (chitotriosidase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000133063:
Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:134111242-134151540
Strand Forward strand
Band E4
Transcripts
ENSMUST00000086475 ENSMUSP00000083666
ENSMUST00000159963 ENSMUSP00000123979
ENSMUST00000160060 ENSMUSP00000124331
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004568 chitinase activity
GO:0008061 chitin binding
GO:0008843 endochitinase activity
Biological Process
GO:0000272 polysaccharide catabolic process
GO:0005975 carbohydrate metabolic process
GO:0006030 chitin metabolic process
GO:0006032 chitin catabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005764 lysosome
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000133063
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
mmu00520
Amino sugar and nucleotide sugar metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00520
Amino sugar and nucleotide sugar metabolism pathway
INOH
PID NCI
Cross-References
SwissProt Q9D7Q1
TrEMBL B2RS82
UniProt Splice Variant
Entrez Gene 71884
UniGene Mm.328268
RefSeq NM_001284524 NM_001284525 NM_027979 XM_006529879 XM_006529880 XM_006529881
OMIM
CCDS CCDS15304 CCDS69943
HPRD
IMGT
MGI ID MGI:1919134
MGI Symbol Chit1
EMBL AK009012 AY458654 AY536287 BC138765 CH466520
GenPept AAI38766 AAR14312 AAS47832 BAB26025 EDL39629
RNA Seq Atlas 71884

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca