Version 5.4
Mus musculus Protein: Elovl6
Summary
InnateDB Protein IDBP-193384.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Elovl6
Protein Name ELOVL family member 6, elongation of long chain fatty acids (yeast)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000071351
InnateDB Gene IDBG-193382 (Elovl6)
Protein Structure
UniProt Annotation
Function Condensing enzyme that catalyzes the synthesis of saturated and monounsaturated fatty acids. Elongates fatty acids with C12, 14 and 16 carbons. {ECO:0000269PubMed:11567032, ECO:0000269PubMed:12032166}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Microsome membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Highly expressed in adrenal gland, liver, white adipose tissue (WAT), adult and fetal brain, cerebellum, spinal cord, testis, skin and peripheral nerve; where lipogenesis and steroidogenesis are active. Weakly expressed in kidney, heart, skeletal muscle, lung, and spleen. {ECO:0000269PubMed:11567032, ECO:0000269PubMed:12032166, ECO:0000269PubMed:12084938}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
Biological Process
GO:0019367 fatty acid elongation, saturated fatty acid
GO:0030497 fatty acid elongation
GO:0042759 long-chain fatty acid biosynthetic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0016021 integral component of membrane
GO:0030176 integral component of endoplasmic reticulum membrane
Protein Structure and Domains
PDB ID MGI:2156528
InterPro IPR002076 GNS1/SUR4 membrane protein
PFAM PF01151
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q920L5
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 170439
UniGene Mm.475605
RefSeq NP_569717
MGI ID
MGI Symbol Elovl6
OMIM
CCDS CCDS38632
HPRD
IMGT
EMBL AB072039 AF480860 AK029029 AK167373 AY053453 BC051041 BC098492 BC100576
GenPept AAH51041 AAH98492 AAI00577 AAL14239 AAM13450 BAB68544 BAC26252 BAE39469

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca