InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Myog

Summary

InnateDB Protein

IDBP-193525.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Myog

Protein Name

myogenin

Synonyms

bHLHc3; MYF4; myo;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027730

InnateDB Gene

IDBG-193523 (Myog)

Protein Structure

UniProt Annotation

Function

Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin- remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Plays also a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts. {ECO:0000269PubMed:15706034, ECO:0000269PubMed:16407395, ECO:0000269PubMed:16424906, ECO:0000269PubMed:16437161, ECO:0000269PubMed:21465538, ECO:0000269PubMed:21798092, ECO:0000269PubMed:22235349, ECO:0000269PubMed:22847234, ECO:0000269PubMed:23364797, ECO:0000269PubMed:8393145, ECO:0000269PubMed:8393146}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00981, ECO:0000269PubMed:16424906}. Note=Recruited to late myogenic gene promoter regulatory sequences with SMARCA4/BRG1/BAF190A and SWI/SNF chromatin-remodeling enzymes to promote chromatin-remodeling and transcription initiation in developing embryos.

Disease Associations

Tissue Specificity

Expressed in myoblast cells. Expressed weakly in myotubes (at protein level). Expressed strongly in denervated muscles and in satellite cells isolated from denervated muscles. Expressed weakly in innervated muscle and in satellite cells isolated from innervated muscles. {ECO:0000269PubMed:21465538, ECO:0000269PubMed:21798092}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	17 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000987	core promoter proximal region sequence-specific DNA binding
GO:0001047	core promoter binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0031490	chromatin DNA binding
GO:0043565	sequence-specific DNA binding
GO:0046983	protein dimerization activity
GO:0070888	E-box binding

Biological Process

GO:0001503	ossification
GO:0006355	regulation of transcription, DNA-templated
GO:0007049	cell cycle
GO:0007517	muscle organ development
GO:0007519	skeletal muscle tissue development
GO:0008285	negative regulation of cell proliferation
GO:0010831	positive regulation of myotube differentiation
GO:0014737	positive regulation of muscle atrophy
GO:0014842	regulation of satellite cell proliferation
GO:0014873	response to muscle activity involved in regulation of muscle adaptation
GO:0014878	response to electrical stimulus involved in regulation of muscle adaptation
GO:0014891	striated muscle atrophy
GO:0014894	response to denervation involved in regulation of muscle adaptation
GO:0014902	myotube differentiation
GO:0042789	mRNA transcription from RNA polymerase II promoter
GO:0045663	positive regulation of myoblast differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048741	skeletal muscle fiber development
GO:0048743	positive regulation of skeletal muscle fiber development
GO:0071158	positive regulation of cell cycle arrest
GO:0071285	cellular response to lithium ion
GO:0071363	cellular response to growth factor stimulus
GO:0071392	cellular response to estradiol stimulus
GO:1901739	regulation of myoblast fusion