Mus musculus Gene: Myog
Summary
InnateDB Gene IDBG-193523.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Myog
Gene Name myogenin
Synonyms bHLHc3; MYF4; myo
Species Mus musculus
Ensembl Gene ENSMUSG00000026459
Encoded Proteins
myogenin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000122180:
Myogenin is a muscle-specific transcription factor that can induce myogenesis in a variety of cell types in tissue culture. It is a member of a large family of proteins related by sequence homology, the helix-loop-helix (HLH) proteins. It is essential for the development of functional skeletal muscle. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:134289989-134292548
Strand Forward strand
Band E4
Transcripts
ENSMUST00000027730 ENSMUSP00000027730
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 17 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000987 core promoter proximal region sequence-specific DNA binding
GO:0001047 core promoter binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0031490 chromatin DNA binding
GO:0043565 sequence-specific DNA binding
GO:0046983 protein dimerization activity
GO:0070888 E-box binding
Biological Process
GO:0001503 ossification
GO:0006355 regulation of transcription, DNA-templated
GO:0007049 cell cycle
GO:0007517 muscle organ development
GO:0007519 skeletal muscle tissue development
GO:0008285 negative regulation of cell proliferation
GO:0010831 positive regulation of myotube differentiation
GO:0014737 positive regulation of muscle atrophy
GO:0014842 regulation of satellite cell proliferation
GO:0014873 response to muscle activity involved in regulation of muscle adaptation
GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation
GO:0014891 striated muscle atrophy
GO:0014894 response to denervation involved in regulation of muscle adaptation
GO:0014902 myotube differentiation
GO:0042789 mRNA transcription from RNA polymerase II promoter
GO:0045663 positive regulation of myoblast differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048741 skeletal muscle fiber development
GO:0048743 positive regulation of skeletal muscle fiber development
GO:0071158 positive regulation of cell cycle arrest
GO:0071285 cellular response to lithium ion
GO:0071363 cellular response to growth factor stimulus
GO:0071392 cellular response to estradiol stimulus
GO:1901739 regulation of myoblast fusion
Cellular Component
GO:0005634 nucleus
GO:0032993 protein-DNA complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Myogenesis pathway
CDO in myogenesis pathway
Developmental Biology pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
ID pathway
REACTOME
CDO in myogenesis pathway
Developmental Biology pathway
Myogenesis pathway
Myogenesis pathway
CDO in myogenesis pathway
Developmental Biology pathway
KEGG
INOH
PID NCI
Regulation of nuclear beta catenin signaling and target gene transcription
Cross-References
SwissProt P12979
TrEMBL
UniProt Splice Variant
Entrez Gene 17928
UniGene Mm.16528 Mm.418674
RefSeq NM_031189
OMIM
CCDS CCDS15306
HPRD
IMGT
MGI ID MGI:97276
MGI Symbol Myog
EMBL BC048683 BC068019 D90156 M95800 X15784
GenPept AAB59676 AAH48683 AAH68019 BAA14187 CAA33785
RNA Seq Atlas 17928