InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pla2g1b

Summary

InnateDB Protein

IDBP-193847.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pla2g1b

Protein Name

phospholipase A2, group IB, pancreas

Synonyms

Pla2a; sPLA2IB;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031495

InnateDB Gene

IDBG-193845 (Pla2g1b)

Protein Structure

UniProt Annotation

Function

PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules.

Subcellular Localization

Secreted. Note=secreted from pancreatic acinar cells in its inactive form. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004623	phospholipase A2 activity
GO:0005102	receptor binding
GO:0005509	calcium ion binding
GO:0047498	calcium-dependent phospholipase A2 activity

Biological Process

GO:0002227	innate immune response in mucosa
GO:0006633	fatty acid biosynthetic process
GO:0006644	phospholipid metabolic process
GO:0009395	phospholipid catabolic process
GO:0019731	antibacterial humoral response
GO:0044240	multicellular organismal lipid catabolic process
GO:0045740	positive regulation of DNA replication
GO:0046470	phosphatidylcholine metabolic process
GO:0050830	defense response to Gram-positive bacterium