Mus musculus Gene: Pla2g1b
Summary
InnateDB Gene IDBG-193845.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pla2g1b
Gene Name phospholipase A2, group IB, pancreas
Synonyms Pla2a; sPLA2IB;
Species Mus musculus
Ensembl Gene ENSMUSG00000029522
Encoded Proteins
phospholipase A2, group IB, pancreas
phospholipase A2, group IB, pancreas
phospholipase A2, group IB, pancreas
phospholipase A2, group IB, pancreas
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170890:
Phospholipase A2 (EC 3.1.1.4) catalyzes the release of fatty acids from glycero-3-phosphocholines. The best known varieties are the digestive enzymes secreted as zymogens by the pancreas of mammals. Sequences of pancreatic PLA2 enzymes from a variety of mammals have been reported. One striking feature of these enzymes is their close homology to venom phospholipases of snakes. Other forms of PLA2 have been isolated from brain, liver, lung, spleen, intestine, macrophages, leukocytes, erythrocytes, inflammatory exudates, chondrocytes, and platelets (Seilhamer et al., 1986 [PubMed 3028739]) .[supplied by OMIM, Mar 2008]
This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:115466262-115474722
Strand Forward strand
Band F
Transcripts
ENSMUST00000031495 ENSMUSP00000031495
ENSMUST00000112071 ENSMUSP00000107702
ENSMUST00000145785 ENSMUSP00000138683
ENSMUST00000125568 ENSMUSP00000120743
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004623 phospholipase A2 activity
GO:0005102 receptor binding
GO:0005509 calcium ion binding
GO:0047498 calcium-dependent phospholipase A2 activity
Biological Process
GO:0002227 innate immune response in mucosa
GO:0006633 fatty acid biosynthetic process
GO:0006644 phospholipid metabolic process
GO:0009395 phospholipid catabolic process
GO:0019731 antibacterial humoral response
GO:0044240 multicellular organismal lipid catabolic process
GO:0045740 positive regulation of DNA replication
GO:0046470 phosphatidylcholine metabolic process
GO:0050830 defense response to Gram-positive bacterium
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0009986 cell surface
GO:0030141 secretory granule
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Acyl chain remodelling of PC pathway
Acyl chain remodelling of PG pathway
Acyl chain remodelling of PS pathway
Acyl chain remodelling of PE pathway
Acyl chain remodelling of PI pathway
Metabolism pathway
Metabolism of lipids and lipoproteins pathway
Glycerophospholipid biosynthesis pathway
Synthesis of PA pathway
Phospholipid metabolism pathway
KEGG
Glycerophospholipid metabolism pathway
Ether lipid metabolism pathway
Arachidonic acid metabolism pathway
Linoleic acid metabolism pathway
alpha-Linolenic acid metabolism pathway
Vascular smooth muscle contraction pathway
Pancreatic secretion pathway
Fat digestion and absorption pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Acyl chain remodelling of PS pathway
Metabolism of lipids and lipoproteins pathway
Acyl chain remodelling of PC pathway
Glycerophospholipid biosynthesis pathway
Acyl chain remodelling of PE pathway
Acyl chain remodelling of PG pathway
Synthesis of PA pathway
Phospholipid metabolism pathway
Metabolism pathway
Acyl chain remodelling of PI pathway
Synthesis of PA pathway
Acyl chain remodelling of PC pathway
Glycerophospholipid biosynthesis pathway
Acyl chain remodelling of PI pathway
Metabolism of lipids and lipoproteins pathway
Metabolism pathway
Acyl chain remodelling of PS pathway
Phospholipid metabolism pathway
Acyl chain remodelling of PE pathway
Acyl chain remodelling of PG pathway
KEGG
Glycerophospholipid metabolism pathway
Ether lipid metabolism pathway
Arachidonic acid metabolism pathway
Linoleic acid metabolism pathway
alpha-Linolenic acid metabolism pathway
Vascular smooth muscle contraction pathway
Pancreatic secretion pathway
Fat digestion and absorption pathway
INOH
PID BIOCARTA
Eicosanoid metabolism [Biocarta view]
P38 mapk signaling pathway [Biocarta view]
Fc epsilon receptor i signaling in mast cells [Biocarta view]
PID NCI
Fc-epsilon receptor I signaling in mast cells
Cross-References
SwissProt Q9Z0Y2
TrEMBL D3YWH2 D3Z1N8 S4R2K6
UniProt Splice Variant
Entrez Gene 18778
UniGene Mm.20190
RefSeq NM_011107 XM_006530198 XM_006530199
OMIM
CCDS CCDS19592
HPRD
IMGT
MGI ID MGI:101842
MGI Symbol Pla2g1b
EMBL AC117735 AF094610 AF094611 AF097637 AF162712 AF187852 AK007730 AK007797 AK008331 AK008664 AK008668 AK008841 AK008934 AK008936 AK009314 AK028104 AK028134 BC145908 BC145910
GenPept AAD19896 AAD45806 AAF02298 AAF44297 AAG27064 AAI45909 AAI45911 BAB25218 BAB25263 BAB25608 BAB25819 BAB25822 BAB25922 BAB25976 BAB25978 BAB26212 BAC25749 BAC25763
RNA Seq Atlas 18778