InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pla2g1b

Summary

InnateDB Gene

IDBG-193845.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pla2g1b

Gene Name

phospholipase A2, group IB, pancreas

Synonyms

Pla2a; sPLA2IB

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029522

Encoded Proteins

IDBP-193847

phospholipase A2, group IB, pancreas

IDBP-256776

phospholipase A2, group IB, pancreas

IDBP-789617

phospholipase A2, group IB, pancreas

IDBP-538978

phospholipase A2, group IB, pancreas

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170890:
Phospholipase A2 (EC 3.1.1.4) catalyzes the release of fatty acids from glycero-3-phosphocholines. The best known varieties are the digestive enzymes secreted as zymogens by the pancreas of mammals. Sequences of pancreatic PLA2 enzymes from a variety of mammals have been reported. One striking feature of these enzymes is their close homology to venom phospholipases of snakes. Other forms of PLA2 have been isolated from brain, liver, lung, spleen, intestine, macrophages, leukocytes, erythrocytes, inflammatory exudates, chondrocytes, and platelets (Seilhamer et al., 1986 [PubMed 3028739]) .[supplied by OMIM, Mar 2008]
This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:115466262-115474722

Strand

Forward strand

Band

Transcripts

ENSMUST00000031495	ENSMUSP00000031495
ENSMUST00000112071	ENSMUSP00000107702
ENSMUST00000145785	ENSMUSP00000138683
ENSMUST00000125568	ENSMUSP00000120743

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004623	phospholipase A2 activity
GO:0005102	receptor binding
GO:0005509	calcium ion binding
GO:0047498	calcium-dependent phospholipase A2 activity

Biological Process

GO:0002227	innate immune response in mucosa
GO:0006633	fatty acid biosynthetic process
GO:0006644	phospholipid metabolic process
GO:0009395	phospholipid catabolic process
GO:0019731	antibacterial humoral response
GO:0044240	multicellular organismal lipid catabolic process
GO:0045740	positive regulation of DNA replication
GO:0046470	phosphatidylcholine metabolic process
GO:0050830	defense response to Gram-positive bacterium