Version 5.4
Mus musculus Gene: Pla2g1b
Summary
InnateDB Gene IDBG-193845.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pla2g1b
Gene Name phospholipase A2, group IB, pancreas
Synonyms Pla2a; sPLA2IB;
Species Mus musculus
Ensembl Gene ENSMUSG00000029522
Encoded Proteins
IDBP-193847
phospholipase A2, group IB, pancreas
IDBP-256776
phospholipase A2, group IB, pancreas
IDBP-789617
phospholipase A2, group IB, pancreas
IDBP-538978
phospholipase A2, group IB, pancreas
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170890:
Phospholipase A2 (EC 3.1.1.4) catalyzes the release of fatty acids from glycero-3-phosphocholines. The best known varieties are the digestive enzymes secreted as zymogens by the pancreas of mammals. Sequences of pancreatic PLA2 enzymes from a variety of mammals have been reported. One striking feature of these enzymes is their close homology to venom phospholipases of snakes. Other forms of PLA2 have been isolated from brain, liver, lung, spleen, intestine, macrophages, leukocytes, erythrocytes, inflammatory exudates, chondrocytes, and platelets (Seilhamer et al., 1986 [PubMed 3028739]) .[supplied by OMIM, Mar 2008]
This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:115466262-115474722
Strand Forward strand
Band F
Transcripts
ENSMUST00000031495 ENSMUSP00000031495
ENSMUST00000112071 ENSMUSP00000107702
ENSMUST00000145785 ENSMUSP00000138683
ENSMUST00000125568 ENSMUSP00000120743
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004623 phospholipase A2 activity
GO:0005102 receptor binding
GO:0005509 calcium ion binding
GO:0047498 calcium-dependent phospholipase A2 activity
Biological Process
GO:0002227 innate immune response in mucosa
GO:0006633 fatty acid biosynthetic process
GO:0006644 phospholipid metabolic process
GO:0009395 phospholipid catabolic process
GO:0019731 antibacterial humoral response
GO:0044240 multicellular organismal lipid catabolic process
GO:0045740 positive regulation of DNA replication
GO:0046470 phosphatidylcholine metabolic process
GO:0050830 defense response to Gram-positive bacterium
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0009986 cell surface
GO:0030141 secretory granule
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
ENSG00000170890
View Gene Order
Ortholuge
SSD Ortholog
Ortholog supports species divergence
ENSBTAG00000026732
Not yet available
Ortholuge
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
REACT_199038
Acyl chain remodelling of PC pathway
REACT_199039
Acyl chain remodelling of PG pathway
REACT_199030
Acyl chain remodelling of PS pathway
REACT_199027
Acyl chain remodelling of PE pathway
REACT_199024
Acyl chain remodelling of PI pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_188641
Glycerophospholipid biosynthesis pathway
REACT_188640
Synthesis of PA pathway
REACT_188643
Phospholipid metabolism pathway
KEGG
mmu00564
Glycerophospholipid metabolism pathway
mmu00565
Ether lipid metabolism pathway
mmu00590
Arachidonic acid metabolism pathway
mmu00591
Linoleic acid metabolism pathway
mmu00592
alpha-Linolenic acid metabolism pathway
mmu04270
Vascular smooth muscle contraction pathway
mmu04972
Pancreatic secretion pathway
mmu04975
Fat digestion and absorption pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_121384
Acyl chain remodelling of PS pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_120829
Acyl chain remodelling of PC pathway
REACT_121401
Glycerophospholipid biosynthesis pathway
REACT_121369
Acyl chain remodelling of PE pathway
REACT_121324
Acyl chain remodelling of PG pathway
REACT_120906
Synthesis of PA pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
REACT_120722
Acyl chain remodelling of PI pathway
REACT_211382
Synthesis of PA pathway
REACT_205553
Acyl chain remodelling of PC pathway
REACT_202421
Glycerophospholipid biosynthesis pathway
REACT_206203
Acyl chain remodelling of PI pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_219139
Metabolism pathway
REACT_224920
Acyl chain remodelling of PS pathway
REACT_218329
Phospholipid metabolism pathway
REACT_204784
Acyl chain remodelling of PE pathway
REACT_207095
Acyl chain remodelling of PG pathway
KEGG
hsa00564
Glycerophospholipid metabolism pathway
hsa00565
Ether lipid metabolism pathway
hsa00590
Arachidonic acid metabolism pathway
hsa00591
Linoleic acid metabolism pathway
hsa00592
alpha-Linolenic acid metabolism pathway
hsa04270
Vascular smooth muscle contraction pathway
hsa04972
Pancreatic secretion pathway
hsa04975
Fat digestion and absorption pathway
INOH
PID BIOCARTA
100180
Eicosanoid metabolism [Biocarta view]
100085
P38 mapk signaling pathway [Biocarta view]
100165
Fc epsilon receptor i signaling in mast cells [Biocarta view]
PID NCI
fcer1pathway
Fc-epsilon receptor I signaling in mast cells
Cross-References
SwissProt Q9Z0Y2
TrEMBL D3YWH2 D3Z1N8 S4R2K6
UniProt Splice Variant
Entrez Gene 18778
UniGene Mm.20190
RefSeq NM_011107 XM_006530198 XM_006530199
OMIM
CCDS CCDS19592
HPRD
IMGT
MGI ID MGI:101842
MGI Symbol Pla2g1b
EMBL AC117735 AF094610 AF094611 AF097637 AF162712 AF187852 AK007730 AK007797 AK008331 AK008664 AK008668 AK008841 AK008934 AK008936 AK009314 AK028104 AK028134 BC145908 BC145910
GenPept AAD19896 AAD45806 AAF02298 AAF44297 AAG27064 AAI45909 AAI45911 BAB25218 BAB25263 BAB25608 BAB25819 BAB25822 BAB25922 BAB25976 BAB25978 BAB26212 BAC25749 BAC25763
RNA Seq Atlas 18778

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca