Mus musculus Gene: Pla2g1b | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-193845.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Pla2g1b | ||||||||||||||||||||||
Gene Name | phospholipase A2, group IB, pancreas | ||||||||||||||||||||||
Synonyms | Pla2a; sPLA2IB; | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000029522 | ||||||||||||||||||||||
Encoded Proteins |
phospholipase A2, group IB, pancreas
phospholipase A2, group IB, pancreas
phospholipase A2, group IB, pancreas
phospholipase A2, group IB, pancreas
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Protein Structure |
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Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170890:
Phospholipase A2 (EC 3.1.1.4) catalyzes the release of fatty acids from glycero-3-phosphocholines. The best known varieties are the digestive enzymes secreted as zymogens by the pancreas of mammals. Sequences of pancreatic PLA2 enzymes from a variety of mammals have been reported. One striking feature of these enzymes is their close homology to venom phospholipases of snakes. Other forms of PLA2 have been isolated from brain, liver, lung, spleen, intestine, macrophages, leukocytes, erythrocytes, inflammatory exudates, chondrocytes, and platelets (Seilhamer et al., 1986 [PubMed 3028739]) .[supplied by OMIM, Mar 2008] This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 5:115466262-115474722 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | F | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Method
Confidence
Comments
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Acyl chain remodelling of PC pathway
Acyl chain remodelling of PG pathway
Acyl chain remodelling of PS pathway
Acyl chain remodelling of PE pathway
Acyl chain remodelling of PI pathway
Metabolism pathway
Metabolism of lipids and lipoproteins pathway
Glycerophospholipid biosynthesis pathway
Synthesis of PA pathway
Phospholipid metabolism pathway
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KEGG |
Glycerophospholipid metabolism pathway
Ether lipid metabolism pathway
Arachidonic acid metabolism pathway
Linoleic acid metabolism pathway
alpha-Linolenic acid metabolism pathway
Vascular smooth muscle contraction pathway
Pancreatic secretion pathway
Fat digestion and absorption pathway
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INOH | |||||||||||||||||||||||
PID BIOCARTA | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Acyl chain remodelling of PS pathway
Metabolism of lipids and lipoproteins pathway
Acyl chain remodelling of PC pathway
Glycerophospholipid biosynthesis pathway
Acyl chain remodelling of PE pathway
Acyl chain remodelling of PG pathway
Synthesis of PA pathway
Phospholipid metabolism pathway
Metabolism pathway
Acyl chain remodelling of PI pathway
Synthesis of PA pathway
Acyl chain remodelling of PC pathway
Glycerophospholipid biosynthesis pathway
Acyl chain remodelling of PI pathway
Metabolism of lipids and lipoproteins pathway
Metabolism pathway
Acyl chain remodelling of PS pathway
Phospholipid metabolism pathway
Acyl chain remodelling of PE pathway
Acyl chain remodelling of PG pathway
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KEGG |
Glycerophospholipid metabolism pathway
Ether lipid metabolism pathway
Arachidonic acid metabolism pathway
Linoleic acid metabolism pathway
alpha-Linolenic acid metabolism pathway
Vascular smooth muscle contraction pathway
Pancreatic secretion pathway
Fat digestion and absorption pathway
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INOH | |||||||||||||||||||||||
PID BIOCARTA |
Eicosanoid metabolism
[Biocarta view]
P38 mapk signaling pathway
[Biocarta view]
Fc epsilon receptor i signaling in mast cells
[Biocarta view]
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PID NCI |
Fc-epsilon receptor I signaling in mast cells
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Cross-References | |||||||||||||||||||||||
SwissProt | Q9Z0Y2 | ||||||||||||||||||||||
TrEMBL | D3YWH2 D3Z1N8 S4R2K6 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 18778 | ||||||||||||||||||||||
UniGene | Mm.20190 | ||||||||||||||||||||||
RefSeq | NM_011107 XM_006530198 XM_006530199 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS19592 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | MGI:101842 | ||||||||||||||||||||||
MGI Symbol | Pla2g1b | ||||||||||||||||||||||
EMBL | AC117735 AF094610 AF094611 AF097637 AF162712 AF187852 AK007730 AK007797 AK008331 AK008664 AK008668 AK008841 AK008934 AK008936 AK009314 AK028104 AK028134 BC145908 BC145910 | ||||||||||||||||||||||
GenPept | AAD19896 AAD45806 AAF02298 AAF44297 AAG27064 AAI45909 AAI45911 BAB25218 BAB25263 BAB25608 BAB25819 BAB25822 BAB25922 BAB25976 BAB25978 BAB26212 BAC25749 BAC25763 | ||||||||||||||||||||||
RNA Seq Atlas | 18778 | ||||||||||||||||||||||