InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CXCL16

Summary

InnateDB Protein

IDBP-19407.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CXCL16

Protein Name

chemokine (C-X-C motif) ligand 16

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000293778

InnateDB Gene

IDBG-19403 (CXCL16)

Protein Structure

UniProt Annotation

Function

Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo. {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Secreted. Note=Also exists as a soluble form.

Disease Associations

Tissue Specificity

Expressed in T-cell areas. Expressed in spleen, lymph nodes, lung, kidney, small intestine and thymus. Weak expression in heart and liver and no expression in brain and bone marrow.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005041	low-density lipoprotein receptor activity
GO:0005044	scavenger receptor activity
GO:0005102	receptor binding
GO:0008009	chemokine activity

Biological Process

GO:0006898	receptor-mediated endocytosis
GO:0006935	chemotaxis
GO:0030307	positive regulation of cell growth
GO:0030335	positive regulation of cell migration
GO:0034097	response to cytokine
GO:0034341	response to interferon-gamma
GO:0034612	response to tumor necrosis factor
GO:0048247	lymphocyte chemotaxis