InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ralbp1

Summary

InnateDB Protein

IDBP-195145.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ralbp1

Protein Name

ralA binding protein 1

Synonyms

Rip1; RLIP76;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000024905

InnateDB Gene

IDBG-195143 (Ralbp1)

Protein Structure

UniProt Annotation

Function

Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous. The highest level of expression was observed in ovaries and skeletal muscle, whereas the lowest was found in spleen, liver and peripheral blood leukocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0017160	Ral GTPase binding
GO:0030675	Rac GTPase activator activity
GO:0043492	ATPase activity, coupled to movement of substances
GO:0048365	Rac GTPase binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006810	transport
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0032855	positive regulation of Rac GTPase activity
GO:0043089	positive regulation of Cdc42 GTPase activity