InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sfn

Summary

InnateDB Protein

IDBP-195284.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sfn

Protein Name

stratifin

Synonyms

Er; Mme1; Ywhas;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000050374

InnateDB Gene

IDBG-195282 (Sfn)

Protein Structure

UniProt Annotation

Function

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53. {ECO:0000269PubMed:16710422}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:16710422}. Nucleus {ECO:0000269PubMed:16710422}. Secreted {ECO:0000250}. Note=May be secreted by a non-classical secretory pathway. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in the basal layer of skin epithelium and in outer root sheath of hair follicle. {ECO:0000269PubMed:16710422}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 165 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	15 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	165 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0019904	protein domain specific binding
GO:0051219	phosphoprotein binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0001836	release of cytochrome c from mitochondria
GO:0003334	keratinocyte development
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010482	regulation of epidermal cell division
GO:0010839	negative regulation of keratinocyte proliferation
GO:0030216	keratinocyte differentiation
GO:0030307	positive regulation of cell growth
GO:0031424	keratinization
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043588	skin development
GO:0045606	positive regulation of epidermal cell differentiation
GO:0046827	positive regulation of protein export from nucleus
GO:0051726	regulation of cell cycle
GO:0061436	establishment of skin barrier

Cellular Component

GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0030659	cytoplasmic vesicle membrane
GO:0070062	extracellular vesicular exosome