InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Stat6

Summary

InnateDB Protein

IDBP-195604.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Stat6

Protein Name

signal transducer and activator of transcription 6

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000089708

InnateDB Gene

IDBG-195602 (Stat6)

Protein Structure

UniProt Annotation

Function

Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling. {ECO:0000269PubMed:17210636}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 71 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	18 [view]
Protein-DNA	17 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	71 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004871	signal transducer activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0019903	protein phosphatase binding
GO:0042802	identical protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0002296	T-helper 1 cell lineage commitment
GO:0002829	negative regulation of type 2 immune response
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007165	signal transduction
GO:0019221	cytokine-mediated signaling pathway
GO:0033598	mammary gland epithelial cell proliferation
GO:0034097	response to cytokine
GO:0035771	interleukin-4-mediated signaling pathway
GO:0042127	regulation of cell proliferation
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048295	positive regulation of isotype switching to IgE isotypes
GO:0060443	mammary gland morphogenesis
GO:0070301	cellular response to hydrogen peroxide
GO:1902170	cellular response to reactive nitrogen species

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0045121	membrane raft

Protein Structure and Domains

PDB ID

MGI:103034

InterPro

IPR000980 SH2 domain
IPR008967 p53-like transcription factor, DNA-binding
IPR013799 STAT transcription factor, protein interaction
IPR013800 STAT transcription factor, all-alpha
IPR013801 STAT transcription factor, DNA-binding
IPR015988 STAT transcription factor, coiled coil

PFAM

PF00017
PF14633
PF02865
PF01017
PF02864

PRINTS

PR00401

PIRSF

SMART

SM00252
SM00964

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt