InnateDB Protein
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IDBP-195733.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Slc24a6
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Protein Name
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solute carrier family 24 (sodium/potassium/calcium exchanger), member 6
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000064714
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InnateDB Gene
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IDBG-195731 (Slc24a6)
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Protein Structure
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Function |
Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, thereby acting as a key regulator of mitochondrion calcium homeostasis. Regulates rates of glucose-dependent insulin secretion in pancreatic beta- cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses. Able to transport Ca(2+) in exchange of either Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange. In contrast to other members of the family its function is independent of K(+). {ECO:0000269PubMed:20018762}.
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Subcellular Localization |
Mitochondrion inner membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Mainly localizes to mitochondrion inner membrane.Isoform 1: Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Isoform 1 may localize to the endoplasmic reticulum, however such localization is unclear in vivo.Isoform 2: Cell membrane; Multi-pass membrane protein.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed. Expressed in dental tissues. {ECO:0000269PubMed:14625281, ECO:0000269PubMed:22677781}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0005432
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calcium:sodium antiporter activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2180781
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InterPro |
IPR004837
Sodium/calcium exchanger membrane region
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PFAM |
PF01699
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q925Q3
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PhosphoSite |
PhosphoSite-Q925Q3
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TrEMBL |
D3Z5E7
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UniProt Splice Variant |
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Entrez Gene |
170756
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UniGene |
Mm.291070
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RefSeq |
NP_573484
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MGI ID |
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MGI Symbol |
Slc8b1
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OMIM |
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CCDS |
CCDS39238
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HPRD |
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IMGT |
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EMBL |
AC125183
AF261233
AK157173
BC043689
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GenPept |
AAH43689
AAK49407
BAE33988
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