Version 5.4
Mus musculus Gene: Slc24a6
Summary
InnateDB Gene IDBG-195731.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc24a6
Gene Name solute carrier family 24 (sodium/potassium/calcium exchanger), member 6
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000032754
Encoded Proteins
IDBP-195733
solute carrier family 24 (sodium/potassium/calcium exchanger), member 6
IDBP-195735
solute carrier family 24 (sodium/potassium/calcium exchanger), member 6
IDBP-257166
solute carrier family 24 (sodium/potassium/calcium exchanger), member 6
IDBP-257168
solute carrier family 24 (sodium/potassium/calcium exchanger), member 6
IDBP-539981
solute carrier family 24 (sodium/potassium/calcium exchanger), member 6
IDBP-536765
solute carrier family 24 (sodium/potassium/calcium exchanger), member 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000089060:
SLC24A6 belongs to a family of potassium-dependent sodium/calcium exchangers that maintain cellular calcium homeostasis through the electrogenic countertransport of 4 sodium ions for 1 calcium ion and 1 potassium ion (Cai and Lytton, 2004 [PubMed 14625281]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:120511168-120534024
Strand Forward strand
Band F
Transcripts
ENSMUST00000068326 ENSMUSP00000064714
ENSMUST00000076051 ENSMUSP00000075428
ENSMUST00000111890 ENSMUSP00000107521
ENSMUST00000111889 ENSMUSP00000107520
ENSMUST00000147496 ENSMUSP00000120947
ENSMUST00000140329 ENSMUSP00000117260
ENSMUST00000123326
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005432 calcium:sodium antiporter activity
Biological Process
GO:0006851 mitochondrial calcium ion transport
GO:0035725 sodium ion transmembrane transport
GO:0042593 glucose homeostasis
GO:0050796 regulation of insulin secretion
GO:0050896 response to stimulus
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0032592 integral component of mitochondrial membrane
GO:0042383 sarcolemma
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000089060
View Gene Order
ENSBTAG00000011103
Not yet available
Pathways
NETPATH
REACTOME
REACT_247550
SLC-mediated transmembrane transport pathway
REACT_251788
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_236234
Sodium/Calcium exchangers pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19320
Sodium/Calcium exchangers pathway
REACT_19397
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 170756
UniGene Mm.291070
RefSeq NM_001177594 NM_001177595 NM_133221 XM_006530174 XM_006530176
OMIM
CCDS CCDS39238 CCDS51633 CCDS51634
HPRD
IMGT
MGI ID MGI:2180781
MGI Symbol Slc8b1
EMBL
GenPept
RNA Seq Atlas 170756

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca