InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc24a6

Summary

InnateDB Protein

IDBP-195735.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc24a6

Protein Name

solute carrier family 24 (sodium/potassium/calcium exchanger), member 6

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000075428

InnateDB Gene

IDBG-195731 (Slc24a6)

Protein Structure

UniProt Annotation

Function

Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, thereby acting as a key regulator of mitochondrion calcium homeostasis. Regulates rates of glucose-dependent insulin secretion in pancreatic beta- cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses. Able to transport Ca(2+) in exchange of either Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange. In contrast to other members of the family its function is independent of K(+). {ECO:0000269PubMed:20018762}.

Subcellular Localization

Mitochondrion inner membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Mainly localizes to mitochondrion inner membrane.Isoform 1: Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Isoform 1 may localize to the endoplasmic reticulum, however such localization is unclear in vivo.Isoform 2: Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Ubiquitously expressed. Expressed in dental tissues. {ECO:0000269PubMed:14625281, ECO:0000269PubMed:22677781}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005432	calcium:sodium antiporter activity

Biological Process

GO:0006851	mitochondrial calcium ion transport
GO:0035725	sodium ion transmembrane transport
GO:0042593	glucose homeostasis
GO:0050796	regulation of insulin secretion
GO:0050896	response to stimulus
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0032592	integral component of mitochondrial membrane
GO:0042383	sarcolemma