InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UACA

Summary

InnateDB Protein

IDBP-19587.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UACA

Protein Name

uveal autoantigen with coiled-coil domains and ankyrin repeats

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000314556

InnateDB Gene

IDBG-19585 (UACA)

Protein Structure

UniProt Annotation

Function

Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1 (By similarity). {ECO:0000250}.Modulates isoactin dynamics to regulate the morphological alterations required for cell growth and motility. Interaction with ARF6 may modulate cell shape and motility after injury (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:15358194}. Cytoplasm {ECO:0000269PubMed:15358194}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:15358194}. Note=Expressed diffusely in cytoplasm.

Disease Associations

Tissue Specificity

Highly expressed in skeletal muscle, heart, kidney and pancreas. Expressed in choroid, retina and epidermal melanocytes. Expressed in eye muscles and thyroid follicular cells. {ECO:0000269PubMed:11162650, ECO:0000269PubMed:15358194}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0008150	biological_process
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0009411	response to UV
GO:0042307	positive regulation of protein import into nucleus
GO:0042347	negative regulation of NF-kappaB import into nucleus
GO:0043065	positive regulation of apoptotic process
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0050728	negative regulation of inflammatory response

Cellular Component

GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0016020	membrane
GO:0043293	apoptosome
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome