Version 5.4
Mus musculus Protein: Hsd17b6
Summary
InnateDB Protein IDBP-196299.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hsd17b6
Protein Name hydroxysteroid (17-beta) dehydrogenase 6
Synonyms 17betaHSD9; Hsd17b9; Rdh8;
Species Mus musculus
Ensembl Protein ENSMUSP00000026462
InnateDB Gene IDBG-196297 (Hsd17b6)
Protein Structure
UniProt Annotation
Function NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3- alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). {ECO:0000269PubMed:10537158}.
Subcellular Localization Microsome membrane {ECO:0000269PubMed:10537158}; Peripheral membrane protein {ECO:0000269PubMed:10537158}; Lumenal side {ECO:0000269PubMed:10537158}. Early endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Lumenal side {ECO:0000305}.
Disease Associations
Tissue Specificity Detected in liver. {ECO:0000269PubMed:10537158}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004303 estradiol 17-beta-dehydrogenase activity
GO:0004745 retinol dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0047035 testosterone dehydrogenase (NAD+) activity
Biological Process
GO:0008152 metabolic process
GO:0008202 steroid metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0031901 early endosome membrane
Protein Structure and Domains
PDB ID MGI:1351670
InterPro IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002347 Glucose/ribitol dehydrogenase
IPR003560 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
PFAM PF00106
PRINTS PR00080
PR00081
PR01397
PIRSF PIRSF000126
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9R092
PhosphoSite PhosphoSite-Q9R092
TrEMBL
UniProt Splice Variant
Entrez Gene 27400
UniGene Mm.26719
RefSeq NP_038814
MGI ID
MGI Symbol Hsd17b6
OMIM
CCDS CCDS24257
HPRD
IMGT
EMBL AF103797 AK008212 BC021836
GenPept AAF04761 AAH21836 BAB25536

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca