InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mybbp1a

Summary

InnateDB Protein

IDBP-196767.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mybbp1a

Protein Name

MYB binding protein (P160) 1a

Synonyms

AL024407; AU019902; P160; p160MBP; p67MBP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000044827

InnateDB Gene

IDBG-196765 (Mybbp1a)

Protein Structure

UniProt Annotation

Function

May activate or repress transcription via interactions with sequence specific DNA-binding proteins. Repression may be mediated at least in part by histone deacetylase activity (HDAC activity). {ECO:0000269PubMed:11956195, ECO:0000269PubMed:14744933}.

Subcellular Localization

Nucleus, nucleolus. Cytoplasm. Note=Predominantly nucleolar. Also shuttles between the nucleus and cytoplasm. Nuclear import may be mediated by KPNA2, while export appears to depend partially on XPO1/CRM1.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:9447996}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 71 interaction(s) predicted by orthology.

Experimentally validated
Total	36 [view]
Protein-Protein	36 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	71 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003887	DNA-directed DNA polymerase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0006261	DNA-dependent DNA replication
GO:0006351	transcription, DNA-templated
GO:0006913	nucleocytoplasmic transport
GO:0022904	respiratory electron transport chain
GO:0042149	cellular response to glucose starvation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0071158	positive regulation of cell cycle arrest
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0042564	NLS-dependent protein nuclear import complex
GO:0043231	intracellular membrane-bounded organelle