InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Il16

Summary

InnateDB Protein

IDBP-197074.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Il16

Protein Name

interleukin 16

Synonyms

mKIAA4048;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000001792

InnateDB Gene

IDBG-197072 (Il16)

Protein Structure

UniProt Annotation

Function

Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane.Isoform 2 is involved in cell cycle progression in T- cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.

Subcellular Localization

Secreted {ECO:0000250}.Isoform 1: Cytoplasm {ECO:0000269PubMed:10479680}. Note=Colocalizes with GRIN2C in neuronal cell bodies and neurites.Isoform 2: Cytoplasm. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoform 1 is expressed in neurons of the cerebellum and hippocampus. Isoform 2 is expressed in thymus, spleen and lung.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0030595	leukocyte chemotaxis
GO:0050930	induction of positive chemotaxis