InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Folh1

Summary

InnateDB Protein

IDBP-197815.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Folh1

Protein Name

folate hydrolase

Synonyms

GCP2; mopsm;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000001824

InnateDB Gene

IDBG-197813 (Folh1)

Protein Structure

UniProt Annotation

Function

Has both folate hydrolase and N-acetylated-alpha-linked- acidic dipeptidase (NAALADase) activity. Has a preference for tri- alpha-glutamate peptides (By similarity). In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. {ECO:0000250}.Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC. {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed predominantly in the hippocampal region of the brain and in kidney. Lower levels in the ovary, testis and mandibular gland.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004180	carboxypeptidase activity
GO:0008233	peptidase activity
GO:0008237	metallopeptidase activity
GO:0016805	dipeptidase activity
GO:0046872	metal ion binding