Mus musculus Gene: Folh1
Summary
InnateDB Gene IDBG-197813.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Folh1
Gene Name folate hydrolase 1
Synonyms GCP2; mopsm;
Species Mus musculus
Ensembl Gene ENSMUSG00000001773
Encoded Proteins
folate hydrolase
folate hydrolase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000086205:
This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:86719352-86775864
Strand Reverse strand
Band D3
Transcripts
ENSMUST00000001824 ENSMUSP00000001824
ENSMUST00000107271 ENSMUSP00000102892
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004180 carboxypeptidase activity
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0016805 dipeptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0006760 folic acid-containing compound metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Alanine, aspartate and glutamate metabolism pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
Alanine, aspartate and glutamate metabolism pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O35409
TrEMBL Q0VDM6
UniProt Splice Variant
Entrez Gene 53320
UniGene Mm.269137
RefSeq NM_001159706 NM_016770
OMIM
CCDS CCDS21436 CCDS52300
HPRD
IMGT
MGI ID MGI:1858193
MGI Symbol Folh1
EMBL AC099606 AC138674 AF026380 AK002920 BC119604 BC119605
GenPept AAB81971 AAI19605 AAI19606 BAB22457
RNA Seq Atlas 53320