InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CYP46A1

Summary

InnateDB Protein

IDBP-19790.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP46A1

Protein Name

cytochrome P450, family 46, subfamily A, polypeptide 1

Synonyms

CP46; CYP46;

Species

Homo sapiens

Ensembl Protein

ENSP00000261835

InnateDB Gene

IDBG-19788 (CYP46A1)

Protein Structure

UniProt Annotation

Function

Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol. Has also activity with xenobiotic compounds, such as clotrimazole. {ECO:0000269PubMed:18621681, ECO:0000269PubMed:20667828}.

Subcellular Localization

Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in brain. The mRNA was broadly distributed with higher levels in gray matter zones and lower levels in regions rich in white matter. Not detected in fetal sample but its expression increases linearly with age.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0008395	steroid hydroxylase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding
GO:0033781	cholesterol 24-hydroxylase activity

Biological Process

GO:0006699	bile acid biosynthetic process
GO:0006707	cholesterol catabolic process
GO:0006805	xenobiotic metabolic process
GO:0007399	nervous system development
GO:0008206	bile acid metabolic process
GO:0016125	sterol metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process