Homo sapiens Protein: CYP46A1 | |||||||||||||||||
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Summary | |||||||||||||||||
InnateDB Protein | IDBP-19790.6 | ||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||
Gene Symbol | CYP46A1 | ||||||||||||||||
Protein Name | cytochrome P450, family 46, subfamily A, polypeptide 1 | ||||||||||||||||
Synonyms | CP46; CYP46; | ||||||||||||||||
Species | Homo sapiens | ||||||||||||||||
Ensembl Protein | ENSP00000261835 | ||||||||||||||||
InnateDB Gene | IDBG-19788 (CYP46A1) | ||||||||||||||||
Protein Structure |
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UniProt Annotation | |||||||||||||||||
Function | Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol. Has also activity with xenobiotic compounds, such as clotrimazole. {ECO:0000269PubMed:18621681, ECO:0000269PubMed:20667828}. | ||||||||||||||||
Subcellular Localization | Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein. | ||||||||||||||||
Disease Associations | |||||||||||||||||
Tissue Specificity | Expressed in brain. The mRNA was broadly distributed with higher levels in gray matter zones and lower levels in regions rich in white matter. Not detected in fetal sample but its expression increases linearly with age. | ||||||||||||||||
Comments | |||||||||||||||||
Interactions | |||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||
PDB ID | |||||||||||||||||
InterPro |
IPR001128
Cytochrome P450 IPR002401 Cytochrome P450, E-class, group I IPR002403 Cytochrome P450, E-class, group IV |
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PFAM |
PF00067
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PRINTS |
PR00385
PR00463 PR00465 |
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PIRSF | |||||||||||||||||
SMART | |||||||||||||||||
TIGRFAMs | |||||||||||||||||
Post-translational Modifications | |||||||||||||||||
Modification | |||||||||||||||||
Cross-References | |||||||||||||||||
SwissProt | Q9Y6A2 | ||||||||||||||||
PhosphoSite | PhosphoSite-Q9Y6A2 | ||||||||||||||||
TrEMBL | |||||||||||||||||
UniProt Splice Variant | |||||||||||||||||
Entrez Gene | 10858 | ||||||||||||||||
UniGene | Hs.25121 | ||||||||||||||||
RefSeq | NP_006659 | ||||||||||||||||
HUGO | HGNC:2641 | ||||||||||||||||
OMIM | 604087 | ||||||||||||||||
CCDS | CCDS9954 | ||||||||||||||||
HPRD | 04970 | ||||||||||||||||
IMGT | |||||||||||||||||
EMBL | AF094480 AK090886 AK295216 AL136000 AL160313 BC022539 | ||||||||||||||||
GenPept | AAD41244 AAH22539 BAC03539 BAG58210 | ||||||||||||||||