Homo sapiens Protein: CYP46A1
Summary
InnateDB Protein IDBP-19790.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CYP46A1
Protein Name cytochrome P450, family 46, subfamily A, polypeptide 1
Synonyms CP46; CYP46;
Species Homo sapiens
Ensembl Protein ENSP00000261835
InnateDB Gene IDBG-19788 (CYP46A1)
Protein Structure
UniProt Annotation
Function Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol. Has also activity with xenobiotic compounds, such as clotrimazole. {ECO:0000269PubMed:18621681, ECO:0000269PubMed:20667828}.
Subcellular Localization Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.
Disease Associations
Tissue Specificity Expressed in brain. The mRNA was broadly distributed with higher levels in gray matter zones and lower levels in regions rich in white matter. Not detected in fetal sample but its expression increases linearly with age.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005506 iron ion binding
GO:0008395 steroid hydroxylase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0033781 cholesterol 24-hydroxylase activity
Biological Process
GO:0006699 bile acid biosynthetic process
GO:0006707 cholesterol catabolic process
GO:0006805 xenobiotic metabolic process
GO:0007399 nervous system development
GO:0008206 bile acid metabolic process
GO:0016125 sterol metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR002403 Cytochrome P450, E-class, group IV
PFAM PF00067
PRINTS PR00385
PR00463
PR00465
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y6A2
PhosphoSite PhosphoSite-Q9Y6A2
TrEMBL
UniProt Splice Variant
Entrez Gene 10858
UniGene Hs.25121
RefSeq NP_006659
HUGO HGNC:2641
OMIM 604087
CCDS CCDS9954
HPRD 04970
IMGT
EMBL AF094480 AK090886 AK295216 AL136000 AL160313 BC022539
GenPept AAD41244 AAH22539 BAC03539 BAG58210