InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CYP46A1

Summary

InnateDB Gene

IDBG-19788.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP46A1

Gene Name

cytochrome P450, family 46, subfamily A, polypeptide 1

Synonyms

CP46; CYP46

Species

Homo sapiens

Ensembl Gene

ENSG00000036530

Encoded Proteins

IDBP-19790

cytochrome P450, family 46, subfamily A, polypeptide 1

IDBP-19792

cytochrome P450, family 46, subfamily A, polypeptide 1

IDBP-593742

cytochrome P450, family 46, subfamily A, polypeptide 1

IDBP-587060

cytochrome P450, family 46, subfamily A, polypeptide 1

IDBP-586182

cytochrome P450, family 46, subfamily A, polypeptide 1

IDBP-590239

cytochrome P450, family 46, subfamily A, polypeptide 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:99684304-99727301

Strand

Forward strand

Band

q32.2

Transcripts

ENST00000261835	ENSP00000261835
ENST00000380228	ENSP00000369577
ENST00000554611	ENSP00000451069
ENST00000554176	ENSP00000450553
ENST00000554917	ENSP00000452151
ENST00000556313	ENSP00000451602
ENST00000556822

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0008395	steroid hydroxylase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding
GO:0033781	cholesterol 24-hydroxylase activity

Biological Process

GO:0006699	bile acid biosynthetic process
GO:0006707	cholesterol catabolic process
GO:0006805	xenobiotic metabolic process
GO:0007399	nervous system development
GO:0008206	bile acid metabolic process
GO:0016125	sterol metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process