InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bcl10

Summary

InnateDB Protein

IDBP-198755.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bcl10

Protein Name

B-cell leukemia/lymphoma 10

Synonyms

AI132454; BCL-10; C81403; CARMEN; cE10; CIPER; CLAP; ME10;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029842

InnateDB Gene

IDBG-198751 (Bcl10)

Protein Structure

UniProt Annotation

Function

Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex (By similarity). Is a substrate for MALT1 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Membrane raft {ECO:0000250}. Note=Colocalized with DPP4 in membrane rafts. {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. Detected in developing brain, olfactory epithelium, tongue, whisker follicles, salivary gland, heart, lung, liver and intestinal epithelia of stage 15 embryos.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.

Experimentally validated
Total	30 [view]
Protein-Protein	30 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	50 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0008134	transcription factor binding
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0019209	kinase activator activity
GO:0019899	enzyme binding
GO:0019900	kinase binding
GO:0019901	protein kinase binding
GO:0031625	ubiquitin protein ligase binding
GO:0042803	protein homodimerization activity
GO:0043130	ubiquitin binding
GO:0043422	protein kinase B binding
GO:0043621	protein self-association
GO:0046982	protein heterodimerization activity
GO:0051059	NF-kappaB binding

Biological Process

GO:0001783	B cell apoptotic process
GO:0001843	neural tube closure
GO:0002237	response to molecule of bacterial origin
GO:0002906	negative regulation of mature B cell apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006968	cellular defense response
GO:0007249	I-kappaB kinase/NF-kappaB signaling
GO:0008219	cell death
GO:0009620	response to fungus
GO:0016064	immunoglobulin mediated immune response
GO:0031398	positive regulation of protein ubiquitination
GO:0032094	response to food
GO:0042327	positive regulation of phosphorylation
GO:0042981	regulation of apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087	innate immune response
GO:0045416	positive regulation of interleukin-8 biosynthetic process
GO:0045576	mast cell activation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0050852	T cell receptor signaling pathway
GO:0050856	regulation of T cell receptor signaling pathway
GO:0050870	positive regulation of T cell activation
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051259	protein oligomerization
GO:0051260	protein homooligomerization
GO:0070231	T cell apoptotic process
GO:0071260	cellular response to mechanical stimulus
GO:1900119	positive regulation of execution phase of apoptosis
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0001772	immunological synapse
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0005829	cytosol
GO:0005881	cytoplasmic microtubule
GO:0032449	CBM complex
GO:0042101	T cell receptor complex
GO:0043234	protein complex
GO:0045121	membrane raft
GO:0046696	lipopolysaccharide receptor complex
GO:0048471	perinuclear region of cytoplasm