Version 5.4
Mus musculus Gene: Bcl10
Summary
InnateDB Gene IDBG-198751.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Bcl10
Gene Name B cell leukemia/lymphoma 10
Synonyms AI132454; BCL-10; C81403; CARMEN; cE10; CIPER; CLAP; ME10
Species Mus musculus
Ensembl Gene ENSMUSG00000028191
Encoded Proteins
IDBP-198755
B-cell leukemia/lymphoma 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 18806265
[Homo sapiens] BCL10 and MALT1 are essential mediators of NF-kappaB activation in response to the triggering of a diverse array of transmembrane receptors, including antigen receptors.
PMID 17540779
[Homo sapiens] BCL10 mediates LPS-induced activation of NF-kappaB and IL8 in human intestinal epithelial cells.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000142867:
This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:145924378-145934283
Strand Forward strand
Band H2
Transcripts
ENSMUST00000029842 ENSMUSP00000029842
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.
Experimentally validated
Total 30 [view]
Protein-Protein 30 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 50 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0008134 transcription factor binding
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0019209 kinase activator activity
GO:0019899 enzyme binding
GO:0019900 kinase binding
GO:0019901 protein kinase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042803 protein homodimerization activity
GO:0043130 ubiquitin binding
GO:0043422 protein kinase B binding
GO:0043621 protein self-association
GO:0046982 protein heterodimerization activity
GO:0051059 NF-kappaB binding
Biological Process
GO:0001783 B cell apoptotic process
GO:0001843 neural tube closure
GO:0002237 response to molecule of bacterial origin
GO:0002906 negative regulation of mature B cell apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006968 cellular defense response
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0008219 cell death
GO:0009620 response to fungus
GO:0016064 immunoglobulin mediated immune response
GO:0031398 positive regulation of protein ubiquitination
GO:0032094 response to food
GO:0042327 positive regulation of phosphorylation
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087 innate immune response
GO:0045416 positive regulation of interleukin-8 biosynthetic process
GO:0045576 mast cell activation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0050852 T cell receptor signaling pathway
GO:0050856 regulation of T cell receptor signaling pathway
GO:0050870 positive regulation of T cell activation
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051259 protein oligomerization
GO:0051260 protein homooligomerization
GO:0070231 T cell apoptotic process
GO:0071260 cellular response to mechanical stimulus
GO:1900119 positive regulation of execution phase of apoptosis
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0001772 immunological synapse
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005829 cytosol
GO:0005881 cytoplasmic microtubule
GO:0032449 CBM complex
GO:0042101 T cell receptor complex
GO:0043234 protein complex
GO:0045121 membrane raft
GO:0046696 lipopolysaccharide receptor complex
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000142867
View Gene Order
ENSBTAG00000013851
Not yet available
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_188199
Signaling by the B Cell Receptor (BCR) pathway
REACT_225145
Downstream TCR signaling pathway
REACT_205561
FCERI mediated NF-kB activation pathway
REACT_230745
Immune System pathway
REACT_199121
Activation of NF-kappaB in B cells pathway
REACT_188204
Fc epsilon receptor (FCERI) signaling pathway
REACT_229531
Adaptive Immune System pathway
REACT_222648
TCR signaling pathway
REACT_209507
Downstream signaling events of B Cell Receptor (BCR) pathway
KEGG
mmu04660
T cell receptor signaling pathway pathway
mmu04662
B cell receptor signaling pathway pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
INOH website
B cell receptor signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_11
TCR pathway
NetPath_12
BCR pathway
REACTOME
REACT_12555
Downstream TCR signaling pathway
REACT_118656
Activation of NF-kappaB in B cells pathway
REACT_163994
FCERI mediated NF-kB activation pathway
REACT_12526
TCR signaling pathway
REACT_6802
Innate Immune System pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
KEGG
hsa04662
B cell receptor signaling pathway pathway
hsa04660
T cell receptor signaling pathway pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
INOH website
B cell receptor signaling pathway
PID NCI
cd8tcrpathway
TCR signaling in naïve CD8+ T cells
tcr_pathway
TCR signaling in naïve CD4+ T cells
bcr_5pathway
BCR signaling pathway
nfkappabcanonicalpathway
Canonical NF-kappaB pathway
Cross-References
SwissProt Q9Z0H7
TrEMBL B7ZWE5
UniProt Splice Variant
Entrez Gene 12042
UniGene Mm.470321
RefSeq NM_009740
OMIM
CCDS CCDS17897
HPRD
IMGT
MGI ID MGI:1337994
MGI Symbol Bcl10
EMBL AF057701 AF100339 AF127387 AF134396 AJ006289 AK076082 AK140179 AK150883 AK152563 AK152847 AK156890 AK169126 AK172158 BC024379 BC172007 BC172009 CH466532
GenPept AAD15801 AAD16429 AAD32598 AAD39148 AAH24379 AAI72007 AAI72009 BAC36168 BAE24267 BAE29930 BAE31316 BAE31540 BAE33885 BAE40905 BAE42852 CAA06956 EDL11992
RNA Seq Atlas 12042

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca