Version 5.4
Mus musculus Protein: Dnase2b
Summary
InnateDB Protein IDBP-199185.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dnase2b
Protein Name deoxyribonuclease II beta
Synonyms AI526873; Dlad; DnaseIIb;
Species Mus musculus
Ensembl Protein ENSMUSP00000029836
InnateDB Gene IDBG-199181 (Dnase2b)
Protein Structure
UniProt Annotation
Function Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation. {ECO:0000269PubMed:10497274, ECO:0000269PubMed:12944971}.
Subcellular Localization Lysosome {ECO:0000305}.
Disease Associations
Tissue Specificity Highly expressed in the eye lens. Detected in liver, but not in the other tissues tested. {ECO:0000269PubMed:10497274, ECO:0000269PubMed:12944971}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004520 endodeoxyribonuclease activity
GO:0004531 deoxyribonuclease II activity
Biological Process
GO:0006259 DNA metabolic process
GO:0006309 apoptotic DNA fragmentation
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005764 lysosome
Protein Structure and Domains
PDB ID MGI:1913283
InterPro IPR004947 Deoxyribonuclease II
PFAM PF03265
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9QY48
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 56629
UniGene Mm.25853
RefSeq NP_064341
MGI ID
MGI Symbol Dnase2b
OMIM
CCDS CCDS17904
HPRD
IMGT
EMBL AF128888 AF334603 AF334604 AF334605 AF334606 AF334607 AF334608 AK079224 BC075661
GenPept AAF05082 AAH75661 AAL34450 BAC37579

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca