InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bsn

Summary

InnateDB Protein

IDBP-199429.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bsn

Protein Name

bassoon

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000035208

InnateDB Gene

IDBG-199427 (Bsn)

Protein Structure

UniProt Annotation

Function

Is thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act through binding to ERC2/CAST1. Essential in regulated neurotransmitter release from a subset of brain glutamatergic synapses (By similarity). Involved in the formation of the retinal photoreceptor ribbon synapses. {ECO:0000250, ECO:0000269PubMed:12628168, ECO:0000269PubMed:12628169}.

Subcellular Localization

Cytoplasm. Cell junction, synapse, synaptosome. Cytoplasm, cytoskeleton. Note=Localized to the active zone of presynaptic density.

Disease Associations

Tissue Specificity

Expressed in brain and retina. {ECO:0000269PubMed:12628168, ECO:0000269PubMed:12628169}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0015630	microtubule cytoskeleton
GO:0019898	extrinsic component of membrane
GO:0030054	cell junction
GO:0030424	axon
GO:0030425	dendrite
GO:0044306	neuron projection terminus
GO:0045202	synapse
GO:0048786	presynaptic active zone