InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Glul

Summary

InnateDB Protein

IDBP-199437.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Glul

Protein Name

glutamate-ammonia ligase (glutamine synthetase)

Synonyms

Glns; GS;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000083375

InnateDB Gene

IDBG-199433 (Glul)

Protein Structure

UniProt Annotation

Function

Essential for proliferation of fetal skin fibroblasts. This enzyme has 2 functions: it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004351	glutamate decarboxylase activity
GO:0004356	glutamate-ammonia ligase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016595	glutamate binding
GO:0030145	manganese ion binding
GO:0042802	identical protein binding
GO:0045503	dynein light chain binding

Biological Process

GO:0006536	glutamate metabolic process
GO:0006542	glutamine biosynthetic process
GO:0006807	nitrogen compound metabolic process
GO:0008283	cell proliferation
GO:0009267	cellular response to starvation
GO:0009749	response to glucose
GO:0032024	positive regulation of insulin secretion
GO:0050679	positive regulation of epithelial cell proliferation
GO:0051260	protein homooligomerization
GO:0051968	positive regulation of synaptic transmission, glutamatergic

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005791	rough endoplasmic reticulum
GO:0042995	cell projection
GO:0043005	neuron projection
GO:0043204	perikaryon
GO:0043231	intracellular membrane-bounded organelle
GO:0043234	protein complex
GO:0043679	axon terminus
GO:0044297	cell body
GO:0070062	extracellular vesicular exosome
GO:0097386	glial cell projection